INT243133

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
astrocytes 2
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 96.32 Very High Very High Very High
Nerve growth factor 6 76.56 Quite High
nociceptor 44 66.80 Quite High
imagery 8 65.92 Quite High
Mechanotransduction 3 50.00 Quite Low
antagonist 10 45.56 Quite Low
Potency 1 36.68 Quite Low
bradykinin 1 24.56 Low Low
Pain 4 22.64 Low Low
agonist 4 14.52 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 34 98.44 Very High Very High Very High
Pain 2 22.64 Low Low
Ganglion Cysts 13 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Vibrio Infection 2 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it is likely that UTP activation of P2Y2 leads to a Gq-dependent potentiation of the RA current which does not require prior activation of PKC.
Positive_regulation (leads) of Positive_regulation (activation) of P2Y2 associated with kinase c and rheumatoid arthritis
1) Confidence 0.24 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.31 Pain Relevance 0.51
Taken together these data imply that activation of P2Y2/P2Y4 receptors on astrocytes causes inhibition of SCO.
Positive_regulation (causes) of Positive_regulation (activation) of P2Y2 in astrocytes
2) Confidence 0.19 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03

General Comments

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