INT24317

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Context Info
Confidence 0.54
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.46
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (Gli1) DNA binding (Gli1) cytoplasm (Gli1)
cytosol (Gli1) nucleus (Gli1) molecular_function (Gli1)
Anatomy Link Frequency
plasma 1
neurons 1
auditory cortex 1
Gli1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 87.56 High High
metalloproteinase 6 85.04 High High
primary somatosensory cortex 2 67.28 Quite High
fibrosis 6 61.12 Quite High
Chronic pancreatitis 2 48.92 Quite Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Somatosensory cortex 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 18 98.48 Very High Very High Very High
Fibrosis 6 61.12 Quite High
Injury 2 52.08 Quite High
Pancreatitis 2 48.92 Quite Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, reduction of Gli-1 expression with RNA interference augmented Ihh-stimulated PSC migration.
Gene_expression (expression) of Gli-1 associated with primary sclerosing cholangitis
1) Confidence 0.54 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.68 Pain Relevance 0.14
Unexpectedly, however, adenovirus-mediated Gli-1 overexpression blocked the Ihh enhancement of both MT1-MMP localization on the plasma membrane and PSC migration.
Gene_expression (overexpression) of Gli-1 in plasma associated with primary sclerosing cholangitis
2) Confidence 0.54 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.78 Pain Relevance 0.20
A role for the adenylate cyclase pathway in regulating GLI peptide biosynthesis is also suggested.
Gene_expression (biosynthesis) of GLI
3) Confidence 0.50 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0.09
In the auditory cortex, we distinguished Te1 and Te3V, on the basis of Nissl-GLI and RORbeta expression.
Gene_expression (expression) of Nissl-GLI in auditory cortex
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0.03
The local density of neurons was expressed as a GLI, which indicates the pixel intensity of each image [36]–[38].
Gene_expression (expressed) of GLI in neurons
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0

General Comments

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