INT2432

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 41
Total Number 47
Disease Relevance 31.10
Pain Relevance 16.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cp) oxidoreductase activity (Cp) aging (Cp)
extracellular region (Cp)
Anatomy Link Frequency
blood vessels 2
lung 2
livers 1
caudate-putamen 1
optic nerve 1
Cp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 222 100.00 Very High Very High Very High
qutenza 13 100.00 Very High Very High Very High
Nerve growth factor 5 100.00 Very High Very High Very High
Inflammation 313 99.96 Very High Very High Very High
alcohol 7 99.68 Very High Very High Very High
Morphine 9 99.60 Very High Very High Very High
imagery 17 99.32 Very High Very High Very High
dopamine receptor 1 99.26 Very High Very High Very High
Hippocampus 9 98.64 Very High Very High Very High
rheumatoid arthritis 29 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 301 100.00 Very High Very High Very High
Pancreatic Cancer 38 100.00 Very High Very High Very High
Urological Neuroanatomy 9 100.00 Very High Very High Very High
Heart Rate Under Development 1 100.00 Very High Very High Very High
INFLAMMATION 320 99.96 Very High Very High Very High
Syndrome 8 99.90 Very High Very High Very High
Hyperlipidemia 2 99.90 Very High Very High Very High
Alcohol Addiction 3 99.76 Very High Very High Very High
Stress 49 99.54 Very High Very High Very High
Disease 41 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its close association with active chronic gastritis and even active duodenitis, and the disappearance of these pathologic conditions with antimicrobial treatment suggest a pathogenic role for Cp in active chronic gastritis.
Positive_regulation (role) of Cp associated with duodenitis and gastritis
1) Confidence 0.67 Published 1988 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3047854 Disease Relevance 1.31 Pain Relevance 0.07
Simulation demonstrated that supplemental release of sufentanil from the implant (as might occur with local heating) increases Cp an average of 2.5-2.8% per hours supplemental dose.
Positive_regulation (increases) of Cp
2) Confidence 0.60 Published 2003 Journal Anesthesiology Section Body Doc Link 14508328 Disease Relevance 0 Pain Relevance 0
Histological analysis showed an invasive action of HPbetaCD on the stratum corneum (SC) of rat skin, which could only reduce the lag time (T(L)) but could not increase the J(s) of CP.
Neg (not) Positive_regulation (increase) of CP in skin associated with qutenza
3) Confidence 0.47 Published 2008 Journal Int J Pharm Section Abstract Doc Link 18417302 Disease Relevance 0 Pain Relevance 0.84
Our previous studies have shown that the induction of NGF and ceruloplasmin is preserved when this receptor is deleted [31,34].
Positive_regulation (induction) of ceruloplasmin associated with nerve growth factor
4) Confidence 0.45 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.68 Pain Relevance 0.12
These data suggest that pathologic changes of CP can be shown by imaging techniques.
Positive_regulation (changes) of CP associated with imagery and chronic pancreatitis
5) Confidence 0.45 Published 1995 Journal Zhonghua Wai Ke Za Zhi Section Abstract Doc Link 7587670 Disease Relevance 0.65 Pain Relevance 0.83
Arterial blood pressure and heart rate increased significantly after the application of CP compared with the baseline values and with those of the Control group.
Positive_regulation (increased) of CP in heart associated with heart rate under development
6) Confidence 0.39 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11524357 Disease Relevance 0.16 Pain Relevance 0.15
Also, patients under CAT had a 20% increase in their Cp(ss)95, indicating an increased resistance to the effect of cisatracurium.
Positive_regulation (increase) of Cp
7) Confidence 0.39 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673889 Disease Relevance 0.14 Pain Relevance 0.18
Alcohol (66%) was the major cause of CP and the cause was unknown in 21%.
Positive_regulation (cause) of CP associated with chronic pancreatitis and alcohol
8) Confidence 0.38 Published 2003 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 12544201 Disease Relevance 1.12 Pain Relevance 0.84
The serum insulin concentrations were increased in rats given CH and CP, but not in the other groups, when compared with TB rats.
Neg (not) Positive_regulation (increased) of CP
9) Confidence 0.37 Published 1992 Journal Ups. J. Med. Sci. Section Abstract Doc Link 1523732 Disease Relevance 0.25 Pain Relevance 0.22
Demographic features and clinical presentation are predictive of underlying CP in patients with pancreatic-mass lesions.


Positive_regulation (underlying) of CP
10) Confidence 0.35 Published 2005 Journal Gastrointest. Endosc. Section Body Doc Link 16246688 Disease Relevance 0 Pain Relevance 0
In comparison with control group, the degranulation ratios (DGR) of mast cells in MA and EA groups increased significantly (P < 0.05); while compared with MA and EA groups separately, DGR of the corresponding CP + MA and DSCP + MA, and CP + EA and DSCP + EA groups decreased markedly (P < 0.05), displaying an inhibition of mast cell degranulation following CP and DSCP in ST36 area.
Positive_regulation (corresponding) of CP in mast cell
11) Confidence 0.33 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 19097502 Disease Relevance 0 Pain Relevance 0
Rats treated with the same dose of CP 1 day prior to killing showed a significant decrease in microsomal morphine-UGT activity at 0.05 and 2.5 mM morphine, but a significant increase in activity was observed following administration of CP or Adriamycin (AD; 10 mg/kg) 4 days prior to killing.
Positive_regulation (increase) of CP associated with morphine
12) Confidence 0.30 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1510722 Disease Relevance 0 Pain Relevance 0.55
Cp protein is increased in sera from hyperglycemic patients [70] and after optic nerve crush [71].
Positive_regulation (increased) of Cp in optic nerve
13) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.82 Pain Relevance 0.17
Cp transcript is also increased in retinal Müller cells of diabetic rats [30] which may secrete this protein and ultimately impact retinal microvasculature.
Positive_regulation (increased) of Cp associated with diabetes mellitus
14) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.85 Pain Relevance 0.19
It has been proposed that upregulation of Cp protects against oxidative damage by decreasing ferritin levels and reducing AGE-mediated damage [72].
Positive_regulation (upregulation) of Cp
15) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.81 Pain Relevance 0.16
It has already been demonstrated that chronic treatment with the dopamine receptor blocker, haloperidol, results in an increase of proenkephalin-A-derived peptides in the caudate-putamen (CP).
Positive_regulation (increase) of CP in caudate-putamen associated with dopamine receptor
16) Confidence 0.27 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617455 Disease Relevance 0 Pain Relevance 0.34
CP was induced in adult rats by an intraductal injection of TNBS.
Positive_regulation (induced) of CP associated with chronic pancreatitis
17) Confidence 0.27 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16645160 Disease Relevance 0.84 Pain Relevance 0.74
Imipramine and amphetamine were both effective in displacing previously accumulated CP from the tissue slices.
Positive_regulation (accumulated) of CP
18) Confidence 0.26 Published 1980 Journal Toxicology Section Abstract Doc Link 7414614 Disease Relevance 0.07 Pain Relevance 0.19
A review of patients who underwent CP between October 2005 and May 2009 at St.
Positive_regulation (underwent) of CP
19) Confidence 0.23 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2743692 Disease Relevance 0.36 Pain Relevance 0.06
This protein is a component of the acute phase response, and is induced by inflammation [67], [68] as well as interleukin-1 stimulation [69], although Cp upregulation appears to constitute an anti-inflammatory cytoprotective response [67].
Positive_regulation (upregulation) of Cp associated with acute-phase reaction and inflammation
20) Confidence 0.21 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.90 Pain Relevance 0.17

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