INT24320

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Context Info
Confidence 0.77
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.63
Pain Relevance 0.29

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cilium (Gli1) DNA binding (Gli1) cytoplasm (Gli1)
cytosol (Gli1) nucleus (Gli1) molecular_function (Gli1)
Anatomy Link Frequency
intestinal cells 1
Gli1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 5 95.88 Very High Very High Very High
cytokine 6 71.96 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 95.24 Very High Very High Very High
Skin Cancer 1 94.56 High High
Malignant Neoplastic Disease 2 93.40 High High
Necrosis 1 80.72 Quite High
Injury 7 68.04 Quite High
Wound Healing 2 59.28 Quite High
Corneal Neovascularization 6 54.72 Quite High
Burns 6 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the mol wt distribution of the stored and secreted GLI peptides was determined in control and (Bu)2 cAMP-stimulated samples, 68 +/- 2% of the peptide corresponded to glicentin, while the remainder eluted with the same distribution coefficient as oxyntomodulin.
Localization (secreted) of GLI
1) Confidence 0.77 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0.07
All of these agents were found to stimulate GLI peptide release, to 120-230% of paired control values (P less than 0.05-0.001).
Localization (release) of GLI
2) Confidence 0.77 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0
GLI peptide secretion by the cells was not altered by several pancreatic glucagon secretagogues (cortisol, bombesin, and prostaglandins E1 and D2), but was stimulated by the opioid peptide beta-endorphin (1 microM; P less than 0.02).
Localization (secretion) of GLI associated with opioid
3) Confidence 0.67 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0.09
Some of the mechanisms underlying intestinal glucagon-like immunoreactive (GLI) peptide secretion from cultured fetal rat intestinal cells were investigated using modulators of the adenylate cyclase pathway [(Bu)2cAMP, theophylline, isobutylmethylxanthine], calcium fluxes (ionomycin, A23187), and protein kinase-C (phorbol ester).
Localization (secretion) of GLI in intestinal cells
4) Confidence 0.59 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0
These studies have indicated that the control of secretion of fetal rat intestinal GLI peptides is complex, involving activation of any one or a combination of the three major second messenger systems.
Localization (secretion) of GLI
5) Confidence 0.59 Published 1988 Journal Endocrinology Section Abstract Doc Link 2454801 Disease Relevance 0 Pain Relevance 0.10
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Localization (translocated) of Gli
6) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

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