INT243208

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.21
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
leukocyte 2
T lymphocytes 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 21 97.72 Very High Very High Very High
cytokine 17 73.84 Quite High
Neuronal excitability 1 53.64 Quite High
Multiple sclerosis 54 50.00 Quite Low
gABA 1 47.24 Quite Low
Glutamate 1 46.88 Quite Low
Neurotransmitter 1 46.16 Quite Low
ischemia 4 14.08 Low Low
antiepileptic Drug 9 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 97.72 Very High Very High Very High
Brain Injury 2 96.92 Very High Very High Very High
Cerebral Malaria 62 96.44 Very High Very High Very High
Convulsion 58 96.04 Very High Very High Very High
Epilepsy 66 95.20 Very High Very High Very High
Adhesions 12 88.52 High High
Hypothermia 5 87.12 High High
Disease 17 85.16 High High
Neurodegenerative Disease 1 73.52 Quite High
Demyelinating Disease 55 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these observations, it is plausible to assume that HBO prevents BBB breakdown and then avoids vascular leakage by down-regulating the inflammatory immune response in ECM, but mainly, by reducing the percentage of brain-sequestered CD8+ T lymphocytes [10].
Negative_regulation (prevents) of Protein_catabolism (breakdown) of BBB in T lymphocytes associated with inflammation and cerebral malaria
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518956 Disease Relevance 0.58 Pain Relevance 0.09
Moreover, inhibition of BBB breakdown by blockade of leukocyte-endothelial interaction with an anti-VLA-4 antibody has preventive as well as therapeutic effects in a mouse model of epilepsy [10].
Negative_regulation (inhibition) of Protein_catabolism (breakdown) of BBB in leukocyte associated with epilepsy
2) Confidence 0.04 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 1.62 Pain Relevance 0.18

General Comments

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