INT243236

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl)
Anatomy Link Frequency
neuronal 1
ganglion cells 1
Nefl (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 10 5.00 Very Low Very Low Very Low
GABAergic 10 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 128 92.68 High High
Neurodegenerative Disease 18 76.88 Quite High
Nerve Degeneration 1 72.08 Quite High
Neurological Disease 2 68.40 Quite High
Motor Neuron Diseases 4 68.32 Quite High
Sprains And Strains 2 63.68 Quite High
Disease 15 63.64 Quite High
Targeted Disruption 42 62.08 Quite High
Death 4 28.08 Quite Low
Toxicity 9 21.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynein and dynactin have multiple cellular house-keeping roles which include retrograde axonal transport, neurotrophic factor signalling, neurofilament transport, mRNA localization, neuronal migration, and protein recycling and degradation [32,33].
Localization (localization) of neurofilament in neuronal
1) Confidence 0.73 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.54 Pain Relevance 0
Perhaps this difference is due to the following factors: interspecies variations in neurofilament expression, which have been reported [28-30]; variations in immunostaining techniques with NF-L antibody [30]; or the localization of NF-L immunoreactivity primarily in axons and dendrites, but not in somata, which results in difficulties in visualizing labeled somata and undercounts of the number of NF-L immunolabeled ganglion cells.
Localization (localization) of NF-L in ganglion cells associated with ganglion cysts
2) Confidence 0.46 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.63 Pain Relevance 0
Colocalization of CFP and NF-L immunoreactivities was determined from confocal images of the GCL from five retinal wholemounts (Table 1).
Localization (Colocalization) of NF-L
3) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.40 Pain Relevance 0

General Comments

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