INT243240

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.91
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
sensory neurons 1
ganglion cells 1
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 225 99.08 Very High Very High Very High
nociceptor 96 71.64 Quite High
mu opioid receptor 12 60.80 Quite High
calcitonin gene related peptide 33 56.72 Quite High
Neuropeptide 12 5.00 Very Low Very Low Very Low
Somatostatin 10 5.00 Very Low Very Low Very Low
substance P 9 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Serotonin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 148 100.00 Very High Very High Very High
Ganglion Cysts 319 99.08 Very High Very High Very High
Repression 21 94.20 High High
Neurodegenerative Disease 10 22.44 Low Low
Pain 9 5.00 Very Low Very Low Very Low
Nociception 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Runx3 is one of a small number of genes activated by VP16-Brn3a that are also decreased in the Brn3a knockout, indicating that Brn3a acts primarily as a transcriptional repressor in the early phase of TG development.
Transcription (transcriptional repressor) of Brn3a associated with targeted disruption and trigeminal ganglion
1) Confidence 0.68 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.54 Pain Relevance 0.31
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis.

Transcription (transcription) of Brn3a in sensory neurons associated with ganglion cysts and trigeminal ganglion
2) Confidence 0.59 Published 2010 Journal Neural Dev Section Title Doc Link PMC2829025 Disease Relevance 0.58 Pain Relevance 0.31
Runx3 is one of a small number of genes activated by VP16-Brn3a that are also decreased in the Brn3a knockout, indicating that Brn3a acts primarily as a transcriptional repressor in the early phase of TG development.
Transcription (transcriptional repressor) of VP16-Brn3a associated with targeted disruption and trigeminal ganglion
3) Confidence 0.59 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.56 Pain Relevance 0.32
Antibodies to Brn3a, a POU domain transcription factor, have also been extensively used in studies to label ganglion cells [44,46].
Transcription (transcription) of Brn3a in ganglion cells associated with ganglion cysts
4) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.23 Pain Relevance 0

General Comments

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