INT24326

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1988
Last Reported 2011
Negated 6
Speculated 7
Reported most in Abstract
Documents 346
Total Number 354
Disease Relevance 218.67
Pain Relevance 184.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
nerve 96
skin 14
bladder 11
neurons 11
spinal cord 10
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4103 100.00 Very High Very High Very High
Inflammation 2116 100.00 Very High Very High Very High
Pain 994 100.00 Very High Very High Very High
cytokine 733 100.00 Very High Very High Very High
substance P 690 100.00 Very High Very High Very High
Neuropeptide 395 100.00 Very High Very High Very High
nociceptor 305 100.00 Very High Very High Very High
Hyperalgesia 289 100.00 Very High Very High Very High
antagonist 223 100.00 Very High Very High Very High
Calcitonin gene-related peptide 214 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2248 100.00 Very High Very High Very High
Cancer 1150 100.00 Very High Very High Very High
Pain 913 100.00 Very High Very High Very High
Targeted Disruption 716 100.00 Very High Very High Very High
Hyperalgesia 402 100.00 Very High Very High Very High
Necrosis 160 100.00 Very High Very High Very High
Inflammatory Pain 87 100.00 Very High Very High Very High
Viral Infection 16 100.00 Very High Very High Very High
Ganglion Cysts 1079 99.98 Very High Very High Very High
Injury 769 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal studies have since shown that site-specific viral-mediated expression of NGF in the lumbar dorsal root ganglia prevents peripheral nerve dysfunction associated with chemically induced neuropathy.
Gene_expression (expression) of NGF in peripheral nerve associated with nerve growth factor, induced neuropathy and neuropathic pain
1) Confidence 0.78 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16427624 Disease Relevance 0.71 Pain Relevance 0.51
Using a Herpes simplex virus expression vector, we have investigated the effect of localized NGF expression in a genetic mouse model of progressive diabetic neuropathy, the +/+ Leprdb mouse.
Gene_expression (expression) of NGF associated with nerve growth factor, herpes simplex virus and diabetic neuropathy
2) Confidence 0.78 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16427624 Disease Relevance 0.82 Pain Relevance 0.66
Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor.
Gene_expression (overexpressing) of nerve growth factor in nerve associated with targeted disruption, qutenza and nerve growth factor
3) Confidence 0.78 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 9476901 Disease Relevance 0.64 Pain Relevance 0.70
Two lineages of CCSP-NGF transgenic mice overexpressed NGF in the lung and developed a hyperinnervation of the airways.
Gene_expression (overexpressed) of NGF in lung associated with targeted disruption and nerve growth factor
4) Confidence 0.78 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9476901 Disease Relevance 0.59 Pain Relevance 0.65
We conclude that NGF overexpression from a lung-specific promoter produces anatomic and functional changes in lung innervation, and that CCSP-NGF mice will be useful for studying the role of neurogenic inflammation in airway disease.
Gene_expression (overexpression) of NGF in lung associated with inflammation, nerve growth factor, disease and neurogenic inflammation
5) Confidence 0.78 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9476901 Disease Relevance 0.49 Pain Relevance 0.68
Mice that overexpress nerve growth factor (NGF-OE) in the skin have double the normal number of cutaneous sensory neurons, have increased innervation of the skin and spinal cord, and are hyperalgesic.
Gene_expression (overexpress) of NGF in spinal cord associated with hyperalgesia, nerve growth factor and spinal cord
6) Confidence 0.78 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10493751 Disease Relevance 0.09 Pain Relevance 0.33
Mice that overexpress nerve growth factor (NGF-OE) in the skin have double the normal number of cutaneous sensory neurons, have increased innervation of the skin and spinal cord, and are hyperalgesic.
Gene_expression (overexpress) of nerve growth factor in spinal cord associated with hyperalgesia, nerve growth factor and spinal cord
7) Confidence 0.78 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10493751 Disease Relevance 0.09 Pain Relevance 0.31
Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors.
Gene_expression (Overexpression) of nerve growth factor in skin associated with nerve growth factor and nociceptor
8) Confidence 0.78 Published 1999 Journal J. Neurosci. Section Title Doc Link 10493751 Disease Relevance 0.09 Pain Relevance 0.78
The present study demonstrates that novel sympathetic projections to sensory neurons are also induced in transgenic mice that overexpress nerve growth factor (NGF) in the skin.
Gene_expression (overexpress) of nerve growth factor in nerve associated with targeted disruption and nerve growth factor
9) Confidence 0.78 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.83 Pain Relevance 0.35
These results indicate that NGF can induce novel sympathetic projections to sensory neurons in vivo and suggests a model in which increased NGF expression plays a role in the development of sympathetic hyperalgesia after nerve injury.
Gene_expression (expression) of NGF in sensory neurons associated with hyperalgesia, nervous system injury and nerve growth factor
10) Confidence 0.78 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.81 Pain Relevance 0.53
Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons.
Gene_expression (Overexpression) of nerve growth factor in sympathetic associated with targeted disruption and nerve growth factor
11) Confidence 0.78 Published 1994 Journal J. Comp. Neurol. Section Title Doc Link 7852636 Disease Relevance 0.84 Pain Relevance 0.35
However, reverse transcriptase polymerase chain reaction analysis showed no apparent expression of transgene mRNA in sensory ganglia, suggesting that the additional NGF was derived from increased NGF expression in the skin.
Gene_expression (expression) of NGF in skin associated with nerve growth factor
12) Confidence 0.78 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.78 Pain Relevance 0.59
The present study demonstrates that novel sympathetic projections to sensory neurons are also induced in transgenic mice that overexpress nerve growth factor (NGF) in the skin.
Gene_expression (overexpress) of NGF in nerve associated with targeted disruption and nerve growth factor
13) Confidence 0.78 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.88 Pain Relevance 0.35
Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice.
Gene_expression (overexpression) of NGF associated with pain and neuropathic pain
14) Confidence 0.78 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9714463 Disease Relevance 0.51 Pain Relevance 0.79
We investigated effects of chronic constriction injury (CCI) on behavior and sprouting in mice in which NGF overexpression is driven by a glial protein (GFAP) promotor.
Gene_expression (overexpression) of NGF associated with nerve growth factor, eae and injury
15) Confidence 0.78 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9714463 Disease Relevance 0.53 Pain Relevance 0.69
These results demonstrate a connection between the endogenous ectopic overexpression of NGF and (1) neuropathic pain behaviour and (2) sympathetic sprouting in the DRG.
Gene_expression (overexpression) of NGF in DRG associated with nerve growth factor and neuropathic pain
16) Confidence 0.78 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9714463 Disease Relevance 0.57 Pain Relevance 0.70
We report here that transgenic expression of NGF under control of the K14 keratin promoter can rescue some elements of the peripheral nervous system and restore normal growth and viability to ngf-/- mice.
Gene_expression (expression) of NGF in peripheral nervous system associated with targeted disruption and peripheral nervous system
17) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15010204 Disease Relevance 0.40 Pain Relevance 0.12
Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF.
Gene_expression (expression) of NGF in skin associated with targeted disruption and nociceptor
18) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15010204 Disease Relevance 0.42 Pain Relevance 0.62
Transgenic mice constitutively overexpressing NGF in the airways (Clara-cell secretory protein promoter [CCSP]-NGF-tg) were employed and compared with wild-type animals.
Gene_expression (overexpressing) of NGF associated with targeted disruption and nerve growth factor
19) Confidence 0.78 Published 2002 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12231491 Disease Relevance 0.94 Pain Relevance 0.72
These results indicate that DADLE is one of the most potent agents in increasing the NGF in the biological system and that this action of DADLE involves selective increases of c-Jun and c-Fos, transcription factors that promote the NGF expression.
Gene_expression (expression) of NGF associated with nerve growth factor
20) Confidence 0.78 Published 2005 Journal Synapse Section Abstract Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox