INT243267

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.72
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC40A1) transmembrane transport (SLC40A1) cytoplasm (SLC40A1)
Anatomy Link Frequency
macrophages 1
enterocytes 1
SLC40A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 92.16 High High
cytokine 9 92.04 High High
fibrosis 16 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 7 98.72 Very High Very High Very High
Anaemia 76 98.54 Very High Very High Very High
Aging 2 96.72 Very High Very High Very High
INFLAMMATION 13 92.16 High High
Iron Overload 144 87.80 High High
Chronic Renal Failure 15 84.96 Quite High
Renal Disease 6 70.00 Quite High
Protein Deficiency 2 69.00 Quite High
Renal Insufficiency 1 59.12 Quite High
Repression 4 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the iron exporter gene ferroportin (FPN1) is significantly upregulated, potentially exacerbating the cytosolic iron deficiency.
Positive_regulation (upregulated) of ferroportin associated with anaemia
1) Confidence 0.41 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.40 Pain Relevance 0
In particular, the iron exporter gene ferroportin (FPN1) is significantly upregulated, potentially exacerbating the cytosolic iron deficiency.
Positive_regulation (upregulated) of FPN1 associated with anaemia
2) Confidence 0.41 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.40 Pain Relevance 0
FPN1 is highly expressed in macrophages of the reticuloendothelial system and enterocytes in the duodenum and mediates iron release.
Positive_regulation (mediates) of FPN1 in enterocytes
3) Confidence 0.39 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2519060 Disease Relevance 0.88 Pain Relevance 0.13
Anemia, hypoxia, and erythropoiesis decrease hepcidin gene expression, thereby stabilizing ferroportin and increasing circulating iron available for erythropoiesis [6].
Positive_regulation (stabilizing) of ferroportin associated with anaemia and hypoxia
4) Confidence 0.02 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 0.58 Pain Relevance 0.09
During red cell senescence, iron is released into macrophages in the reticuloendothelial system (RES) and is stored as ferritin and hemosiderin; again, egress of iron from the macrophage is ferroportin dependent [4] (Figure 1).
Positive_regulation (dependent) of ferroportin in macrophages associated with aging
5) Confidence 0.02 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 0.45 Pain Relevance 0

General Comments

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