INT243268

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.18
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC40A1) transmembrane transport (SLC40A1) cytoplasm (SLC40A1)
Anatomy Link Frequency
enterocytes 1
SLC40A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 92.04 High High
Inflammation 3 91.64 High High
Pain 9 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 92 100.00 Very High Very High Very High
Stress 22 99.76 Very High Very High Very High
Porphyria 20 99.28 Very High Very High Very High
Iron Overload 98 98.00 Very High Very High Very High
INFLAMMATION 3 91.64 High High
Repression 8 91.60 High High
Sprains And Strains 24 90.84 High High
Hypoxia 9 90.80 High High
Ataxia 96 81.52 Quite High
Disease 123 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FPN1 is highly expressed in macrophages of the reticuloendothelial system and enterocytes in the duodenum and mediates iron release.
Gene_expression (expressed) of FPN1 in enterocytes
1) Confidence 0.60 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2519060 Disease Relevance 0.86 Pain Relevance 0.13
The GLRX5 knockdown activates IRPs and thereby decreases the level of ALAS2 expression and interrupts heme biosynthesis, but activated IRPs cannot repress FPN1b expression, which is induced during the stress response to mitochondrial iron overload and worsens cytosolic iron deficiency in eythroid cells (Figure 3).
Gene_expression (expression) of FPN1b associated with stress, anaemia, porphyria and iron overload
2) Confidence 0.45 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.10 Pain Relevance 0
However, recently another contributing factor has also been identified, because it appears that mitochondrial iron overload causes oxidative stress which leads to activation of genes that combat oxidative stress, including expression of the iron exporter ferroportin (32).
Gene_expression (expression) of ferroportin associated with stress and iron overload
3) Confidence 0.39 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.81 Pain Relevance 0
101), are activated, and they repress synthesis of proteins such as ferritin and ferroportin, which are encoded by transcripts that contain an IRP binding site in the 5?
Gene_expression (synthesis) of ferroportin
4) Confidence 0.39 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.63 Pain Relevance 0
In particular, the iron exporter gene ferroportin (FPN1) is significantly upregulated, potentially exacerbating the cytosolic iron deficiency.
Gene_expression (deficiency) of FPN1 associated with anaemia
5) Confidence 0.39 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.46 Pain Relevance 0
Expression of iron-regulated proteins in Vibrio spp. has been related to increased virulence in animal models, but the role of heme utilization proteins in bacterial survival under oxidative stress and their effect on the production of pathogenic factors such as hemolysin is unknown.
Gene_expression (Expression) of iron-regulated associated with stress
6) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2996184 Disease Relevance 0.32 Pain Relevance 0

General Comments

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