INT24327

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Context Info
Confidence 0.64
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.61
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tgfa) extracellular region (Tgfa) plasma membrane (Tgfa)
nucleus (Tgfa)
Anatomy Link Frequency
blood 1
brain 1
body 1
Tgfa (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 7 100.00 Very High Very High Very High
peptic ulcer disease 1 98.12 Very High Very High Very High
fibrosis 1 95.64 Very High Very High Very High
Nerve growth factor 1 78.20 Quite High
Enkephalin 1 76.00 Quite High
qutenza 4 45.84 Quite Low
alcohol 2 16.60 Low Low
Calcitonin gene-related peptide 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 7 100.00 Very High Very High Very High
Targeted Disruption 103 99.98 Very High Very High Very High
Malignant Neoplastic Disease 7 99.64 Very High Very High Very High
Hepatocellular Cancer 28 98.40 Very High Very High Very High
Disease 5 98.12 Very High Very High Very High
Ulcers 2 97.80 Very High Very High Very High
Gastritis 1 97.12 Very High Very High Very High
Injury 72 97.00 Very High Very High Very High
Adenocarcinoma 5 96.12 Very High Very High Very High
Fibrosis 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain.
Gene_expression (synthesizing) of transforming growth factor-alpha mRNA in brain
1) Confidence 0.64 Published 1988 Journal J. Neurosci. Section Title Doc Link 2455024 Disease Relevance 0 Pain Relevance 0.12
Using such a TGFa-transgene-expressing TG mouse model whose gastric mucosa showed a strong resistance to ethanol injury (Figure 2), we found that the integrative mechanisms of TGFa involve at least three categories of cytoprotective regulators: NO synthases in relation with gastric blood flow, COX-2, and apoptosis-associated regulators such as Bcl-2 and Bax.
Gene_expression (expressing) of TGFa in blood associated with targeted disruption, injury and apoptosis
2) Confidence 0.32 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.63 Pain Relevance 0
Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor alpha (TGF alpha) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation.
Gene_expression (expression) of transforming growth factor alpha associated with adenocarcinoma
3) Confidence 0.29 Published 2010 Journal Exp. Anim. Section Abstract Doc Link 20660988 Disease Relevance 0.94 Pain Relevance 0.46
The latency of HCC in these transgenic mice is long, but is greatly accelerated by the transgenic overexpression of transforming growth factor-alpha (Murakami et al. 1993; Sargent et al. 1996, 1999; Santoni-Rugiu et al. 1999).
Gene_expression (overexpression) of transforming growth factor-alpha associated with targeted disruption and hepatocellular cancer
4) Confidence 0.21 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.15 Pain Relevance 0
BACKGROUND & AIMS: Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth.
Gene_expression (overexpressed) of transforming growth factor alpha associated with targeted disruption, malignant neoplastic disease and chronic pancreatitis
5) Confidence 0.20 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9322532 Disease Relevance 0.30 Pain Relevance 0.19
An increasing body of evidence suggests that transforming growth factor-alpha (TGF alpha) produced by the gastric mucosa is a critical mediator of gastric mucosal homeostasis.
Gene_expression (produced) of transforming growth factor-alpha in body
6) Confidence 0.18 Published 1995 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8774988 Disease Relevance 0.58 Pain Relevance 0.10

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