INT243271

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.46
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Hrh4) plasma membrane (Hrh4) signal transducer activity (Hrh4)
Anatomy Link Frequency
mast cell 3
dendritic cells 1
Hrh4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 162 99.96 Very High Very High Very High
cytokine 93 98.88 Very High Very High Very High
agonist 12 94.20 High High
Serotonin 6 94.08 High High
Inflammation 111 89.76 High High
Peripheral nervous system 3 86.88 High High
nociceptor 6 82.72 Quite High
Central nervous system 3 79.32 Quite High
substance P 9 74.92 Quite High
c fibre 21 63.84 Quite High
Disease Link Frequency Relevance Heat
Pruritus 303 98.80 Very High Very High Very High
Cognitive Disorder 3 95.64 Very High Very High Very High
Targeted Disruption 9 95.44 Very High Very High Very High
Obesity 3 94.68 High High
INFLAMMATION 99 89.76 High High
Airway Remodeling 6 79.48 Quite High
Hypersensitivity 33 77.52 Quite High
Nociception 12 73.52 Quite High
Disease 18 71.12 Quite High
Asthma 129 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it seems likely that the activation of H4R results in the excitation of itch-mediating histamine-sensitive afferents by increasing intracellular Ca2+ levels, as mentioned above for the H1R pathway.


Positive_regulation (activation) of H4R associated with pruritus
1) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2519061 Disease Relevance 0.68 Pain Relevance 0.36
It is well known that the activation of H4R increases intracellular Ca2+ levels; possibly in a phospholipase C-dependent manner in mast cells [43].
Positive_regulation (activation) of H4R in mast cells
2) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2519061 Disease Relevance 0.62 Pain Relevance 0.21
This effect on Th2 cytokines, via a modulation of Th2 activation, may result from a role of H4R in the Th2 priming capability of dendritic cells [6].
Positive_regulation (role) of H4R in dendritic cells associated with cytokine
3) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.31 Pain Relevance 0.40
Cells including basophils, dendritic cells and neutrophil have been shown to release histamine [6,16,17], with low levels sufficient to activate the high affinity H4R, and H4R antagonists effective in mast cell deficient animals [6].
Positive_regulation (activate) of H4R in mast cell associated with antagonist
4) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.65 Pain Relevance 0.47
Summarizing, it appears that activated H1R and H4R are involved in the induction of itch, whereas H3R acts in the reverse manner.
Positive_regulation (activated) of H4R associated with pruritus
5) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2519061 Disease Relevance 0.55 Pain Relevance 0.39
Cells including basophils, dendritic cells and neutrophil have been shown to release histamine [6,16,17], with low levels sufficient to activate the high affinity H4R, and H4R antagonists effective in mast cell deficient animals [6].
Positive_regulation (activate) of H4R in mast cell associated with antagonist
6) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.65 Pain Relevance 0.47

General Comments

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