INT24328

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 97
Total Number 99
Disease Relevance 59.65
Pain Relevance 9.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
fibroblasts 8
HGF 5
central nervous system 2
keratinocyte 2
endothelial cells 2
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 416 100.00 Very High Very High Very High
chemokine 87 100.00 Very High Very High Very High
Chronic pancreatitis 24 100.00 Very High Very High Very High
Nerve growth factor 24 100.00 Very High Very High Very High
Enkephalin 12 99.76 Very High Very High Very High
monoamine 156 99.50 Very High Very High Very High
rheumatoid arthritis 105 99.26 Very High Very High Very High
Taxol 15 97.24 Very High Very High Very High
Central nervous system 63 95.88 Very High Very High Very High
fibrosis 261 94.64 High High
Disease Link Frequency Relevance Heat
Hypoxia 78 100.00 Very High Very High Very High
Pancreatitis 26 100.00 Very High Very High Very High
Pancreatic Cancer 281 99.96 Very High Very High Very High
Salivary Gland Disease 16 99.88 Very High Very High Very High
Cancer 1904 99.84 Very High Very High Very High
Breast Cancer 149 99.84 Very High Very High Very High
Malignant Neoplastic Disease 56 99.64 Very High Very High Very High
Wound Healing 444 99.60 Very High Very High Very High
Adenocarcinoma 47 99.44 Very High Very High Very High
Targeted Disruption 1474 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Special attention was focused when a study by Pedal et al. (10) showed that EGF was involved in scarless wound healing in which increased expression of EGF in the early murine fetal period was found and decreased EGF expression was noted during the scar formation at late pregnancy.
Gene_expression (expression) of EGF associated with cicatrix and wound healing
1) Confidence 0.75 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.32 Pain Relevance 0.11
Special attention was focused when a study by Pedal et al. (10) showed that EGF was involved in scarless wound healing in which increased expression of EGF in the early murine fetal period was found and decreased EGF expression was noted during the scar formation at late pregnancy.
Gene_expression (expression) of EGF associated with cicatrix and wound healing
2) Confidence 0.75 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.31 Pain Relevance 0.11
BACKGROUND & AIMS: Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth.
Gene_expression (overexpressed) of EGF associated with targeted disruption, malignant neoplastic disease and chronic pancreatitis
3) Confidence 0.74 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9322532 Disease Relevance 0.30 Pain Relevance 0.19
BACKGROUND & AIMS: Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth.
Gene_expression (overexpressed) of Epidermal growth factor associated with targeted disruption, malignant neoplastic disease and chronic pancreatitis
4) Confidence 0.74 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9322532 Disease Relevance 0.30 Pain Relevance 0.19
BACKGROUND & AIMS: Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in malignant pancreatic growth.
Gene_expression (overexpressed) of EGF associated with targeted disruption, malignant neoplastic disease and chronic pancreatitis
5) Confidence 0.74 Published 1997 Journal Gastroenterology Section Abstract Doc Link 9322532 Disease Relevance 0.30 Pain Relevance 0.19
Compared to the normal mice, the expressions of EGF increased by ~2.7 and 3.6 folds respectively (P < 0.001) for the groups II and III ulcerated mice.
Gene_expression (expressions) of EGF
6) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.09 Pain Relevance 0
Effect of PK and Omez on EGF expression
Gene_expression (expression) of EGF
7) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.09 Pain Relevance 0
PK showed significantly better effect than Omez (P < 0.01), which increased the EGF expression by 11.6% compared to that of group III mice.
Gene_expression (expression) of EGF
8) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.08 Pain Relevance 0
Administration of the test drugs led to an increased expression of EGF in mucosa of the ulcer margin.
Gene_expression (expression) of EGF in margin associated with ulcers
9) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.10 Pain Relevance 0
EGF expression assay
Gene_expression (expression) of EGF
10) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0 Pain Relevance 0.03
EGF is also reported to stimulate PG synthesis, which, in turn, augments the expression of EGF via a feedback cycle, mediated by the PKA signaling pathway [34].
Gene_expression (expression) of EGF
11) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.44 Pain Relevance 0.08
However, treatment with PK for one and three days augmented the expression of EGF further by 98.1% and 149.0% (P < 0.001) compared to that in the respective ulcerated control mice.
Gene_expression (expression) of EGF
12) Confidence 0.73 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.09 Pain Relevance 0
TGF-alpha-synthesizing cells were localized in brain regions that have been shown to synthesize nerve growth factor, epidermal growth factor (EGF) and enkephalins.
Gene_expression (synthesize) of epidermal growth factor in nerve associated with nerve growth factor and enkephalin
13) Confidence 0.72 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2455024 Disease Relevance 0 Pain Relevance 0.15
TGF-alpha-synthesizing cells were localized in brain regions that have been shown to synthesize nerve growth factor, epidermal growth factor (EGF) and enkephalins.
Gene_expression (synthesize) of EGF in nerve associated with nerve growth factor and enkephalin
14) Confidence 0.72 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2455024 Disease Relevance 0 Pain Relevance 0.15
Immunohistochemical analysis revealed that tumor cells and tumor-associated endothelial cells in control mice expressed activated EGF-R.
Gene_expression (expressed) of EGF-R in endothelial cells associated with cancer
15) Confidence 0.71 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12782601 Disease Relevance 1.26 Pain Relevance 0.20
Treatment with PKI 166 also decreased the expression of phosphorylated EGF-R by tumor cells and tumor-associated endothelial cells, and this was even more pronounced with PKI 166 plus Taxol treatment.
Gene_expression (expression) of EGF-R in endothelial cells associated with cancer and taxol
16) Confidence 0.71 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12782601 Disease Relevance 1.14 Pain Relevance 0.29
Since 1983, recombinant human EGF (rh-EGF) has been produced in large quantities by the recombination of the human EGF gene and expression in microorganisms.
Gene_expression (produced) of rh-EGF
17) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.97 Pain Relevance 0
Since 1983, recombinant human EGF (rh-EGF) has been produced in large quantities by the recombination of the human EGF gene and expression in microorganisms.
Gene_expression (produced) of EGF
18) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.97 Pain Relevance 0
Therefore, it can be reported that EGF stimulates collagen production but produces mature collagen, and that the production in quantity is similar as seen in normal skin.
Gene_expression (produces) of EGF in skin
19) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.92 Pain Relevance 0.28
EGF has been found to be similar to polypeptides such as TGF-?
Gene_expression (similar) of EGF
20) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 0.64 Pain Relevance 0

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