INT24332

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 2010
Negated 8
Speculated 4
Reported most in Body
Documents 28
Total Number 39
Disease Relevance 45.45
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
liver 3
blood 2
fat 2
hepatocyte 1
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 148 100.00 Very High Very High Very High
Catecholamine 5 99.48 Very High Very High Very High
psoriasis 63 99.32 Very High Very High Very High
agonist 386 98.90 Very High Very High Very High
beta blocker 14 98.16 Very High Very High Very High
peptic ulcer disease 4 96.72 Very High Very High Very High
alcohol 101 96.52 Very High Very High Very High
spinal inflammation 8 95.20 Very High Very High Very High
Osteoarthritis 63 94.84 High High
Inflammation 321 94.00 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5135 100.00 Very High Very High Very High
Pressure And Volume Under Development 43 100.00 Very High Very High Very High
Coronary Heart Disease 805 99.96 Very High Very High Very High
Metabolic Syndrome 382 99.92 Very High Very High Very High
Hypertriglyceridemia 48 99.80 Very High Very High Very High
Nicotine Addiction 113 99.66 Very High Very High Very High
Psoriasis 106 99.32 Very High Very High Very High
Peripheral Arterial Disease 8 98.84 Very High Very High Very High
Coronary Artery Disease 118 98.24 Very High Very High Very High
Disease 156 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is likely that the modulation of HDL levels or its properties will significantly impact future approaches to the management of cardiovascular disease in both the primary and secondary prevention settings.
Regulation (modulation) of HDL associated with cardiovascular disease and disorder of lipid metabolism
1) Confidence 0.45 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.50 Pain Relevance 0.06
HDL: an independent CHD risk factor
Neg (independent) Regulation (independent) of HDL associated with coronary heart disease and disorder of lipid metabolism
2) Confidence 0.33 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 2.31 Pain Relevance 0
Lipid molecules, such as HDL and LDL, circulate in the plasma complex with proteins termed lipoproteins, which act as carriers.
Regulation (circulate) of HDL in plasma associated with disorder of lipid metabolism
3) Confidence 0.33 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.53 Pain Relevance 0
These observations have prompted the evaluation of various factors thought to affect HDL and its subspecies, HDL2 and HDL3.
Regulation (affect) of HDL associated with disorder of lipid metabolism
4) Confidence 0.22 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895456 Disease Relevance 0.93 Pain Relevance 0.15
It should be noted that many of the variables affecting HDL levels were not controlled in these studies, and definite conclusions should not be extrapolated to the general population at risk for CHD.
Regulation (affecting) of HDL associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.22 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895456 Disease Relevance 1.07 Pain Relevance 0.17
Currently, well-controlled trials to study the effect of cimetidine on HDL levels are in progress.
Regulation (effect) of HDL associated with disorder of lipid metabolism
6) Confidence 0.22 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895456 Disease Relevance 1.08 Pain Relevance 0.16
Numerous therapeutic agents are being developed in an attempt to modulate serum levels of HDL as well as its functions.
Regulation (modulate) of HDL associated with disorder of lipid metabolism
7) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.47 Pain Relevance 0.04
HDL is a significant, independent risk factor that has been suggested as the next therapeutic target for reducing residual CHD risk.
Regulation (target) of HDL associated with coronary heart disease and disorder of lipid metabolism
8) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.39 Pain Relevance 0.10
agonists in the pipeline that may prove beneficial in improved regulation of lipid metabolism as well as augmentation of HDL levels.


Regulation (regulation) of HDL associated with agonist and disorder of lipid metabolism
9) Confidence 0.20 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.01 Pain Relevance 0.40
One intriguing possibility may be that such an approach to HDL modulation by treating it in acute situations may offer means by which to stabilize vulnerable atheromatous plaques and decrease their propensity to rupture and cause acute coronary events.


Regulation (modulation) of HDL in plaques associated with atherosclerotic plaque, rupture and disorder of lipid metabolism
10) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.13 Pain Relevance 0.04
Multiple new agents that affect HDL metabolism are undergoing trials, and the outcomes of these trials may lead to better therapies in future.
Regulation (affect) of HDL associated with disorder of lipid metabolism
11) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.53 Pain Relevance 0.05
Niacin in millimolar concentrations also inhibited the uptake of HDL–apolipoprotein A-I by HepG2 cells (a model for liver) without affecting the uptake of cholesteryl ester from HDL (Jin et al 1997).
Neg (without) Regulation (affecting) of HDL in liver associated with disorder of lipid metabolism
12) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 1.09 Pain Relevance 0
The in vivo relevance of these findings to endothelial recovery during physiological or pathological conditions remains to be addressed; nevertheless, the results of clinical studies with synthetic HDL, ApoA-I mimetics, and drugs that are becoming available that selectively affect HDL plasma levels and biological functions support the importance of the correction of endothelial function by HDL.



Regulation (affect) of HDL in plasma associated with disorder of lipid metabolism
13) Confidence 0.14 Published 2005 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC1993938 Disease Relevance 0.83 Pain Relevance 0.03
With the exception of hip–waist ratios, the other direct parameters of the metabolic syndrome (elevated triglycerides, reduced high-density lipoprotein (HDL), elevated blood pressure, and elevated blood glucose) were not available in the patients studied.
Neg (not) Regulation (available) of high-density lipoprotein in blood associated with pressure and volume under development, hypertriglyceridemia, metabolic syndrome and disorder of lipid metabolism
14) Confidence 0.10 Published 2009 Journal Skeletal Radiol Section Body Doc Link PMC2773838 Disease Relevance 1.77 Pain Relevance 0.32
Several pharmacologic agents are known to alter HDL levels.
Regulation (alter) of HDL associated with disorder of lipid metabolism
15) Confidence 0.10 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895456 Disease Relevance 1.12 Pain Relevance 0.18
This suggests that low fat diets may adversely affect the most antiatherogenic HDL subpopulation.
Spec (may) Regulation (affect) of HDL in fat associated with disorder of lipid metabolism
16) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.99 Pain Relevance 0.04
Mean fasting blood glucose, mean haemoglobin A1, mean total serum cholesterol, mean high density lipoprotein (HDL) cholesterol and mean serum triglycerides were not affected by nifedipine in any of the three groups over the 14-16 weeks' treatment.
Neg (not) Regulation (affected) of high density lipoprotein in blood associated with disorder of lipid metabolism
17) Confidence 0.08 Published 1987 Journal Eur. Heart J. Section Abstract Doc Link 3450519 Disease Relevance 1.17 Pain Relevance 0.09
Variable changes in HDL-C have been observed in response to exercise.
Regulation (changes) of HDL associated with disorder of lipid metabolism
18) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.10 Pain Relevance 0
Some individuals significantly increase HDL-C levels after 8 weeks of regular aerobic exercise (running), while other individuals may not manifest changes in HDL-C for nearly 2 years (Durstine et al 2001).
Spec (may) Regulation (changes) of HDL associated with disorder of lipid metabolism
19) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.07 Pain Relevance 0
In psoriasis, a decrease of HDL synthesis and HDL structural changes can be observed, due to various biochemical disturbances, such as abnormalities of receptor function, changes of hepatic structure and function, activity changes of hepatocyte membranes, impaired RCT, esterification, and lipases [36].
Regulation (changes) of HDL in hepatocyte associated with psoriasis, congenital anomalies and disorder of lipid metabolism
20) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.60 Pain Relevance 0.14

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