INT24337

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.80
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 4
plasma 2
middle cerebral artery 2
nerve 2
DRG 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 18 100.00 Very High Very High Very High
dorsal root ganglion 14 99.16 Very High Very High Very High
Dorsal horn 1 98.48 Very High Very High Very High
Sciatic nerve 3 98.44 Very High Very High Very High
Locus ceruleus 1 98.16 Very High Very High Very High
gracile nuclei 1 97.68 Very High Very High Very High
Eae 8 96.92 Very High Very High Very High
medulla 12 95.80 Very High Very High Very High
Nerve growth factor 4 94.64 High High
guanethidine 1 89.88 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 16 99.76 Very High Very High Very High
Infarction 1 97.20 Very High Very High Very High
Injury 9 96.92 Very High Very High Very High
Middle Cerebral Artery Infarction 3 96.52 Very High Very High Very High
Neuropathic Pain 4 88.96 High High
Nervous System Injury 4 86.60 High High
Hypotension 1 85.24 High High
Hyperalgesia 1 83.44 Quite High
Stroke 4 68.56 Quite High
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on experiments in the pithed guinea-pig, it is suggested that prejunctional facilitatory beta-adrenoceptors may also be involved in the regulation of the NPY release, since infusion of isoprenaline elicited a facilitation of the PNS-induced increase of plasma NPY-LI levels which could be antagonised by propranolol.
Spec (may) Positive_regulation (involved) of Regulation (regulation) of NPY in plasma
1) Confidence 0.50 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.35
Taken together, our results demonstrate that the activation of ERK and p38 and also the changes in NPY and BDNF expression may occur in different populations of DRG neurons after CCI, partially through alterations in the target-derived NGF.
Positive_regulation (activation) of Regulation (changes) of NPY in neurons associated with dorsal root ganglion, nerve growth factor and eae
2) Confidence 0.49 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.36 Pain Relevance 1.17
Significantly higher NPY immunoreactivity was induced in the injured side DRG neurons, the dorsal horn and the gracile nuclei in middle-aged rats than in young rats.
Positive_regulation (induced) of Regulation (immunoreactivity) of NPY in DRG associated with dorsal root ganglion, gracile nuclei and dorsal horn
3) Confidence 0.47 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10797555 Disease Relevance 0.68 Pain Relevance 0.65
Both neonatal transection of the infraorbital nerve (ION) and application of vinblastine to it resulted in a marked up-regulation of galanin and NPY in V ganglion cells and their central axon arbors in animals killed on postnatal day 6.
Positive_regulation (resulted) of Regulation (regulation) of NPY in nerve associated with ganglion cysts
4) Confidence 0.44 Published 1996 Journal Somatosens Mot Res Section Abstract Doc Link 8844957 Disease Relevance 0.27 Pain Relevance 0.53
Evidence is also presented for the existence of a glucocorticoid regulation of NPY IR neurons, especially of those innervating the locus coeruleus, since after 2 weeks adrenalectomy reduced NPY IR in this area.
Positive_regulation (presented) of Regulation (regulation) of NPY IR in neurons associated with locus ceruleus
5) Confidence 0.39 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455156 Disease Relevance 0.09 Pain Relevance 0.35
Recently, we have shown increases in the immunoreactivity for neuropeptide Y and tyrosine hydroxylase in the insular cortex surrounding the focal infarction after middle cerebral artery occlusion.
Positive_regulation (increases) of Regulation (immunoreactivity) of neuropeptide Y in middle cerebral artery associated with middle cerebral artery infarction, neuropeptide and infarction
6) Confidence 0.33 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9331169 Disease Relevance 0.40 Pain Relevance 0.35

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