INT243477

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.49
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR1) cell-cell signaling (SSTR1) signal transducer activity (SSTR1)
SSTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 216 100.00 Very High Very High Very High
dopamine receptor 2 60.24 Quite High
Dopamine 14 48.72 Quite Low
antagonist 2 43.28 Quite Low
imagery 14 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 18 99.00 Very High Very High Very High
Cancer 326 96.64 Very High Very High Very High
Carcinoid 44 89.36 High High
Adenocarcinoma 6 87.68 High High
Diarrhoea 20 85.92 High High
Alzheimer's Dementia 12 84.80 Quite High
Increased Venous Pressure Under Development 8 84.80 Quite High
Chondrosarcoma 2 79.16 Quite High
Metastasis 30 74.80 Quite High
Disease 50 64.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently the universal or "pan-receptor" somatostatin ligand pasireotide (SOM230) has been developed, which possess high affinity binding to SSTs 2, 3 and 5, moderate affinity for SSTR 1.
SSTR 1 Binding (affinity) of associated with somatostatin
1) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.46 Pain Relevance 0.26
Apoptosis [programmed cell death] seems to be induced by two different processes: interaction with the SSTR 3 [53] and inhibition of the Insulin-like Growth Factor I (IGF I), potent antiapoptotic hormone [60].
SSTR Binding (interaction) of associated with apoptosis
2) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.06 Pain Relevance 0.20
Octreotide has high affinity for somatostatin receptor (SSTR) 2 and SSTR5.
somatostatin receptor Binding (affinity) of associated with somatostatin
3) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 0.98 Pain Relevance 0.10
Octreotide has high affinity for somatostatin receptor (SSTR) 2 and SSTR5.
SSTR Binding (affinity) of associated with somatostatin
4) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 0.98 Pain Relevance 0.10

General Comments

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