INT243480

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.25
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR5) cytoplasm (SSTR5) signal transducer activity (SSTR5)
SSTR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 320 97.40 Very High Very High Very High
imagery 19 87.96 High High
Dopamine 17 77.48 Quite High
palliative 3 67.52 Quite High
Serotonin 6 63.00 Quite High
agonist 11 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
dopamine receptor 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Somatostatinoma 12 99.98 Very High Very High Very High
Gastrinoma 12 99.60 Very High Very High Very High
Glucagonoma 18 98.96 Very High Very High Very High
Insulinoma 36 98.66 Very High Very High Very High
Disease 69 94.36 High High
Carcinoid 66 93.40 High High
Hypoglycemia 15 92.04 High High
Cancer 337 90.80 High High
Pancreatic Cancer 12 88.88 High High
Alzheimer's Dementia 6 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment was effective in all SSTR 2 positive patients and in a few SSTR 2 negative ones, while no relation between treatment effectiveness and the expression of SSTR 5 was observed [36].
Gene_expression (expression) of SSTR 5
1) Confidence 0.55 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.61 Pain Relevance 0.28
Pancreatic insulinomas had heterogeneous SSTRs expression while 100% of somatostatinomas expressed SSTR 5 and 100% gastrinomas and glucagonomas expressed SSTR 2 [11].
Gene_expression (expressed) of SSTR 5 associated with glucagonoma, gastrinoma, insulinoma and somatostatinoma
2) Confidence 0.48 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.75 Pain Relevance 0.34
These effects may be attributable to SSTR 2 which is the most frequently expressed subtype and/or SSTR 5, 1 and 3 which are also expressed [90,91].
Gene_expression (expressed) of SSTR 5
3) Confidence 0.48 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.98 Pain Relevance 0.14
Takei et al. (2007) determined the expression of SSTR2 and SSTR5 by IHC and compared this with the results of octreotide suppression testing before surgery to define whether IHC of SSTR could be associated with the preoperative response to octreotide.
Spec (determined) Gene_expression (expression) of SSTR5
4) Confidence 0.47 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 0.91 Pain Relevance 0.10

General Comments

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