INT243496

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.02
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (FECH) mitochondrion (FECH) small molecule metabolic process (FECH)
Anatomy Link Frequency
skin 2
FECH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 253 100.00 Very High Very High Very High
backache 4 73.88 Quite High
fibrosis 2 69.92 Quite High
Inflammation 4 67.32 Quite High
imagery 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Chronic low back pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Pain score 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 217 100.00 Very High Very High Very High
Erythropoietic Protoporphyria 92 100.00 Very High Very High Very High
Sunburn 30 97.48 Very High Very High Very High
Low Back Pain 38 94.52 High High
Syndrome 6 84.08 Quite High
Marinesco Sjogren Syndrome 1 83.68 Quite High
Disease 46 71.76 Quite High
Cirrhosis 5 70.48 Quite High
Autoimmune Disease 1 65.92 Quite High
Injury 18 64.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study we found a symptom increase in 82% of all subjects and a normalization of pain to pre-FCE levels on the third day following the FCE (Fig. 2).
Positive_regulation (increase) of Gene_expression (levels) of FCE associated with pain
1) Confidence 0.40 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2522381 Disease Relevance 1.15 Pain Relevance 1.09
In our study we found a symptom increase in 82% of all subjects and a normalization of pain to pre-FCE levels on the third day following the FCE (Fig. 2).
Positive_regulation (increase) of Gene_expression (levels) of FCE associated with pain
2) Confidence 0.40 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2522381 Disease Relevance 1.15 Pain Relevance 1.08
Finally, because FECH deficiency causes erythropoietic protoporphyria (EPP), manifesting painful skin photosensitivity due to protoporphyrin accumulation (92), and deficient Fe?
Positive_regulation (causes) of Gene_expression (deficiency) of FECH in skin associated with pain, sunburn and erythropoietic protoporphyria
3) Confidence 0.34 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.80 Pain Relevance 0.10
The discovery that clinical expression of this type of EPP normally required a hypomorphic FECH IVS3-48C allele trans to the mutation was demonstrated in France [26,31] and was independently confirmed by studies from Japan, North America, Sweden, Israel, South Africa, the United Kingdom [28,30-34].
Positive_regulation (required) of Gene_expression (expression) of EPP associated with erythropoietic protoporphyria
4) Confidence 0.09 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.92 Pain Relevance 0.07

General Comments

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