INT243530

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA3) cytoplasm (CA3)
Anatomy Link Frequency
hippocampus 2
CA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 15 99.68 Very High Very High Very High
Pyramidal cell 3 94.80 High High
Glutamate 14 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
excitatory amino acid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 8 99.82 Very High Very High Very High
Convulsion 10 99.04 Very High Very High Very High
Injury 22 96.16 Very High Very High Very High
Shellfish Poisoning 11 90.84 High High
Congenital Anomalies 4 87.92 High High
Toxicity 29 24.40 Low Low
Hemorrhage 3 6.28 Low Low
Pressure And Volume Under Development 7 5.32 Low Low
Poisoning 23 5.00 Very Low Very Low Very Low
Vomiting 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this dose being insufficient to produce seizure or any clinical signs of neurotoxicity, it did induce morphologic changes, predominately in the CA3 region of the hippocampus, including: cytoplasmic vacuolization of neurons and astrocytes, as well as injury to the mitochondria in the pyramidal cells.
Positive_regulation (induce) of Gene_expression (region) of CA3 in hippocampus associated with drug induced neurotoxicity, convulsion, pyramidal cell, injury and hippocampus
1) Confidence 0.10 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.47 Pain Relevance 0.14

General Comments

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