INT243532

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SOX10) DNA binding (SOX10) cytoplasm (SOX10)
Anatomy Link Frequency
plasma 2
SOX10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 45 80.12 Quite High
Neurobehavioral 6 73.36 Quite High
Limbic system 9 42.56 Quite Low
imagery 6 9.92 Low Low
Electroencephalography 3 7.68 Low Low
Glutamate 42 5.00 Very Low Very Low Very Low
Central nervous system 24 5.00 Very Low Very Low Very Low
nMDA receptor 18 5.00 Very Low Very Low Very Low
Glutamate receptor 15 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 87 98.40 Very High Very High Very High
Shellfish Poisoning 33 70.60 Quite High
Drug Induced Neurotoxicity 24 63.92 Quite High
Confusion 3 57.04 Quite High
Convulsion 30 55.60 Quite High
Coma 12 54.88 Quite High
Death 6 54.16 Quite High
Poisoning 69 36.72 Quite Low
Gliosis 24 19.76 Low Low
Brain Injury 6 12.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the fact that DOM is transferred to milk opens the possibility of a risk for neonatal exposure by this route.
Positive_regulation (transferred) of Gene_expression (transferred) of DOM
1) Confidence 0.55 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.42 Pain Relevance 0.07
The authors show transfer of DOM from spiked milk [0.3 and 1.0 mg/kg] to the plasma of nursing neonatal rats with an overall longer DOM retention in milk than in plasma after 8 hr exposure of the dams.
Positive_regulation (transfer) of Gene_expression (transfer) of DOM in plasma
2) Confidence 0.48 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.22 Pain Relevance 0.04
A recent study provides evidence that DOM is transferable in the milk of lactating rats [45].
Positive_regulation (transferable) of Gene_expression (transferable) of DOM
3) Confidence 0.40 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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