INT243536

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (EARS2) RNA binding (EARS2) nucleus (EARS2)
ligase activity (EARS2) cytoplasm (EARS2)
Anatomy Link Frequency
brain 1
EARS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 10 100.00 Very High Very High Very High
Neurotransmitter 6 99.38 Very High Very High Very High
Glutamate 28 98.76 Very High Very High Very High
excitatory amino acid 6 98.06 Very High Very High Very High
ischemia 2 81.76 Quite High
nMDA receptor 12 74.24 Quite High
agonist 8 73.04 Quite High
Central nervous system 16 72.72 Quite High
Hippocampus 30 60.96 Quite High
Multiple sclerosis 2 52.32 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 16 99.84 Very High Very High Very High
Injury 44 96.08 Very High Very High Very High
Brain Disease 10 95.64 Very High Very High Very High
Toxicity 58 91.36 High High
Renal Disease 2 89.16 High High
Brain Hemorrhage 2 82.24 Quite High
Brain Injury 4 80.96 Quite High
Disease 6 53.92 Quite High
Demyelinating Disease 2 52.32 Quite High
Stroke 2 50.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both are excitatory amino acid [EAA] analogues of glutamate, a major excitatory neurotransmitter in the brain that is known to activate glutamate receptors [GluRs].
Positive_regulation (activate) of GluRs in brain associated with neurotransmitter, glutamate, glutamate receptor and excitatory amino acid
1) Confidence 0.11 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.38 Pain Relevance 0.31
Current evidence on DOM induced neurotoxicity supports the view that the main cause of neurotoxicity is the activation of GluRs and the release of endogenous glutamate leading to a cascade of events mediating cell and tissue injury (Figure 8).
Positive_regulation (activation) of GluRs associated with glutamate, drug induced neurotoxicity and injury
2) Confidence 0.08 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 1.04 Pain Relevance 0.22

General Comments

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