INT243538

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.27
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SOX10) DNA binding (SOX10) cytoplasm (SOX10)
Anatomy Link Frequency
area postrema 1
hilus 1
ganglia 1
SOX10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pyramidal cell 15 98.88 Very High Very High Very High
Hippocampus 75 97.92 Very High Very High Very High
Limbic system 15 94.40 High High
Inflammation 10 88.32 High High
Glutamate 70 81.00 Quite High
nMDA receptor 30 64.64 Quite High
Central nervous system 40 53.76 Quite High
tolerance 5 53.68 Quite High
Parenteral administration 5 50.88 Quite High
antagonist 10 46.00 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 145 99.96 Very High Very High Very High
Disease 15 98.32 Very High Very High Very High
Hemorrhage 15 92.44 High High
Pressure And Volume Under Development 35 91.48 High High
Injury 110 90.92 High High
Duodenal Ulcer 5 90.60 High High
Ulcers 5 89.92 High High
INFLAMMATION 10 88.32 High High
Neurodegenerative Disease 10 83.56 Quite High
Dilated Cardiomyopathy 5 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments in rodents and non-human primates indicate that the area postrema is a target for DOM toxicity, suggesting effects on brain stem regions associated with visceral function [101,103,109,110].
Regulation (target) of DOM in area postrema associated with toxicity
1) Confidence 0.31 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.37 Pain Relevance 0.11
Furthermore, the demonstration of GluRs in the ganglia and other structures of the GI tract provide evidence for the molecular target for DOM toxicity in these tissues [132].
Regulation (target) of DOM in ganglia associated with toxicity
2) Confidence 0.31 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.86 Pain Relevance 0.09
The hippocampus (Figure 1) [107], among other brain regions, has been identified as a specific target site having high sensitivity to DOM toxicity, particularly the pyramidal neurons in the CA3, CA4 or hilus of the dentate gyrus [DG] [93,96,98–101,103,104,106,108].
Regulation (sensitivity) of DOM in hilus associated with toxicity, pyramidal cell and hippocampus
3) Confidence 0.31 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.70 Pain Relevance 0.15
Alterations in the pharmacokinetics of DOM, as a function of age, have not been systematically investigated to date.
Spec (investigated) Regulation (Alterations) of DOM
4) Confidence 0.19 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.33 Pain Relevance 0.05
The pineal hormone melatonin appears to be neuroprotective and attenuates the excitotoxic effect of DOM and KA [225,226].
Regulation (effect) of DOM
5) Confidence 0.19 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 1.02 Pain Relevance 0.08

General Comments

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