INT243593

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.14
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
plasma 2
Purkinje cells 1
GABAergic neurons 1
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 45 100.00 Very High Very High Very High
Pyramidal cell 8 100.00 Very High Very High Very High
antagonist 52 98.12 Very High Very High Very High
Thalamus 4 64.04 Quite High
Hippocampus 3 61.80 Quite High
Inflammation 44 50.00 Quite Low
Action potential 11 50.00 Quite Low
cytokine 23 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
Neurotransmitter 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 45 78.24 Quite High
Adhesions 3 60.00 Quite High
INFLAMMATION 45 50.00 Quite Low
Colon Cancer 46 16.92 Low Low
Adenocarcinoma 17 5.00 Very Low Very Low Very Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Metastasis 11 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, SNAP-25a transcripts in Purkinje cells were also greatly decreased relative to GABAergic neurons of the reticular nucleus and the caudate, as well as hippocampal interneurons and pyramidal neurons (Fig. 5C).
Negative_regulation (decreased) of in GABAergic neurons Transcription (transcripts) of Fig in Purkinje cells associated with pyramidal cell and gabaergic
1) Confidence 0.18 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.28
B inhibitor pyrrolidine dithiocarbamate (20), the NFAT-specific inhibitory 3,5-bistrifluoromethyl pyrazole derivative BTP1 (21), and the calcineurin-inhibitor cyclosporine A (22) all blocked the PMA/ionomycin-induced expression of twist1 mRNA (Fig. 3 B), showing that both NFAT and NF-?
Negative_regulation (blocked) of Transcription (expression) of Fig
2) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Ectopic expression of MEK1DD or MEK2DD resulted in the loss of E-cadherin staining at the plasma membrane (Fig. 1E), concomitant with a marked reduction of E-cadherin protein and mRNA levels (Fig. 1F and 1G).
Negative_regulation (reduction) of Transcription (levels) of Fig in plasma
3) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.14 Pain Relevance 0
-induced elevation in COX-2 Luciferase (Fig. 5C) and mRNA expression (Fig. 5D) was significantly inhibited by co-treatment of cells with the FP receptor antagonist (AL8810), and chemical inhibitors of PLC (U73122), PKA (4C3MQ), EGFR kinase (AG1478) and ERK1/2 kinase (PD98059), but not the EP2 receptor antagonist (AH6809), EP4 receptor antagonist (ONOAE2227) or PKC inhibitor (GF109203x; Fig. 5C and D, P < 0.05).


Negative_regulation (inhibited) of Transcription (expression) of Fig associated with antagonist
4) Confidence 0.03 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox