INT24360

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Context Info
Confidence 0.32
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.62
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp6) cytoplasm (Fabp6)
Anatomy Link Frequency
brain 1
TSC 1
heart 1
trunk 1
Fabp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 14 100.00 Very High Very High Very High
Clonidine 7 100.00 Very High Very High Very High
Neuropeptide 7 99.98 Very High Very High Very High
Pain 14 99.16 Very High Very High Very High
hypoalgesia 3 95.72 Very High Very High Very High
Spinal cord 2 93.84 High High
analgesia 19 93.44 High High
Opioid 1 91.20 High High
medulla 7 88.80 High High
Inflammation 5 80.80 Quite High
Disease Link Frequency Relevance Heat
Hypertension 19 100.00 Very High Very High Very High
Low Back Pain 14 100.00 Very High Very High Very High
Stroke 1 100.00 Very High Very High Very High
Nociception 22 99.92 Very High Very High Very High
Pain 14 99.16 Very High Very High Very High
Cognitive Disorder 6 96.84 Very High Very High Very High
Hypoalagesia 3 95.72 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 12 94.08 High High
Sprains And Strains 18 92.52 High High
Sneezing 1 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constant pain, pain that wakes, and stiffness after resting were generally considered as moderate indicators of ILBP, while intermittent pain during the day, pain that develops later in the day, pain on standing for a while, with lifting, bending forward a little, on trunk flexion or extension, doing a sit up, when driving long distances, getting out of a chair, and pain on repetitive bending, running, coughing or sneezing were all generally considered as moderate indicators of MLBP.
ILBP Binding (indicators) of in trunk associated with pain, sneezing and backache
1) Confidence 0.32 Published 2009 Journal Man Ther Section Abstract Doc Link 18555728 Disease Relevance 2.06 Pain Relevance 1.96
To study the role of medullary alpha-adrenoceptors in hypertension, we compared specific binding of [3H]prazosin and [3H]clonidine in different brain regions of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive Wistar-Kyoto rats (WKY).
SHR Binding (binding) of in brain associated with stroke, hypertension and clonidine
2) Confidence 0.32 Published 1989 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2471890 Disease Relevance 0.37 Pain Relevance 0.35
Finally, several studies suggest that the nociception of SHR is not associated with their inherited hypertensive trait [4,7].
SHR Binding (associated) of associated with nociception and hypertension
3) Confidence 0.27 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1802084 Disease Relevance 1.19 Pain Relevance 0.62
The binding with the heart membrane preparation of SHR rats displayed only the high affinity delta-binding site with a Kd of 1.53 nM and a Bmax of 6.5 pmol/g protein.
SHR Binding (binding) of in heart associated with hypertension
4) Confidence 0.02 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 2853850 Disease Relevance 0.65 Pain Relevance 0.31
These findings suggest that the reduced neuropeptide concentrations of the SHR (particularly those within the CSC) and TSC may be a result of, rather than a causal factor in, hypertension.
SHR Binding (concentrations) of in TSC associated with hypertension and neuropeptide
5) Confidence 0.01 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455167 Disease Relevance 0.35 Pain Relevance 0.87

General Comments

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