INT243601

Context Info Confidence 0.08 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)

Nfatc1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 41 50.00 cytokine 23 5.00 Arthritis 15 5.00 Crohn's disease 7 5.00 chemokine 4 5.00 rheumatoid arthritis 4 5.00 Inflammatory response 1 5.00 spinal inflammation 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 42 50.00 Disease 14 5.00 Hypersensitivity 14 5.00 Arthritis 13 5.00 Inflammatory Bowel Disease 8 5.00 Rheumatoid Arthritis 6 5.00 Hyperplasia 4 5.00 Severe Combined Immunodeficiency 4 5.00 Seronegative Spondarthritis 2 5.00 Rheumatic Diseases 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B inhibitor pyrrolidine dithiocarbamate (20), the NFAT-specific inhibitory 3,5-bistrifluoromethyl pyrazole derivative BTP1 (21), and the calcineurin-inhibitor cyclosporine A (22) all blocked the PMA/ionomycin-induced expression of twist1 mRNA (Fig. 3 B), showing that both NFAT and NF-?

Negative_regulation (blocked) of Transcription (expression) of NFAT

1) Confidence 0.08 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0

General Comments

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