INT243603

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.96
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6)
cytoplasm (Stat6) signal transducer activity (Stat6)
Anatomy Link Frequency
nucleus 2
lung 1
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 101 96.72 Very High Very High Very High
cytokine 90 70.56 Quite High
Inflammation 61 70.16 Quite High
chemokine 10 54.84 Quite High
agonist 1 19.68 Low Low
Arthritis 16 5.00 Very Low Very Low Very Low
pruritus 10 5.00 Very Low Very Low Very Low
Crohn's disease 7 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 68 96.92 Very High Very High Very High
Apoptosis 75 92.52 High High
Cancer 118 91.92 High High
Lymphatic System Cancer 102 88.64 High High
Targeted Disruption 17 82.56 Quite High
Fibrosis 58 80.08 Quite High
Mycosis Fungoides 96 75.92 Quite High
Syndrome 62 75.80 Quite High
Asthma 53 74.36 Quite High
INFLAMMATION 68 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following binding, STAT6 is phosphorylated, dimerizes, and translocates to the nucleus.
Localization (translocates) of STAT6 in nucleus
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.50 Pain Relevance 0.19
As STAT-6 is translocated into the nucleus following phosphorylation, the nuclear fraction of protein is enriched with the phosphorylated form.
Localization (translocated) of STAT-6 in nucleus
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
IL-4/STAT6 signaling could not suppress twist1 expression in residual IFN-?
Localization (/) of STAT6
3) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
This was associated with an accumulation of acetylated histones, increased p21WAF1 and bax, decreased Stat6 and phosphor-Stat6, and activation of caspase 3 (Zhang et al 2005).
Localization (decreased) of Stat6
4) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.00 Pain Relevance 0
This was associated with an accumulation of acetylated histones, increased p21WAF1 and bax, decreased Stat6 and phosphor-Stat6, and activation of caspase 3 (Zhang et al 2005).
Localization (decreased) of Stat6
5) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 0.94 Pain Relevance 0
In contrast to deletion of STAT-1 or STAT-6, STAT-3 deletion in mice is lethal and therefore little is known about the role of STAT-3 in lung fibrosis.
Localization (deletion) of STAT-6 in lung associated with fibrosis and pulmonary fibrosis
6) Confidence 0.10 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.52 Pain Relevance 0.21

General Comments

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