INT243616

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.09
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 2
lung 2
cardiogenic 2
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 296 89.80 High High
Arthritis 60 85.60 High High
Bioavailability 4 52.40 Quite High
cytokine 113 51.48 Quite High
adenocard 8 12.56 Low Low
Crohn's disease 28 5.00 Very Low Very Low Very Low
imagery 21 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
Inflammatory response 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 312 89.80 High High
Severe Combined Immunodeficiency 20 88.48 High High
Arthritis 52 85.60 High High
Asthma 94 84.60 Quite High
Pulmonary Disease 216 84.16 Quite High
Teratoma 10 83.60 Quite High
Pneumonia 2 81.68 Quite High
Death 12 79.92 Quite High
Adult Respiratory Distress Syndrome 2 76.48 Quite High
Lung Injury 2 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B are required, but not sufficient, to induce transcription of twist1 in Th cells.
Positive_regulation (induce) of Transcription (transcription) of twist1
1) Confidence 0.69 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
B inhibitor pyrrolidine dithiocarbamate (20), the NFAT-specific inhibitory 3,5-bistrifluoromethyl pyrazole derivative BTP1 (21), and the calcineurin-inhibitor cyclosporine A (22) all blocked the PMA/ionomycin-induced expression of twist1 mRNA (Fig. 3 B), showing that both NFAT and NF-?
Positive_regulation (induced) of Transcription (expression) of twist1
2) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
B cannot induce transcription of twist1 on their own, but require concerted binding of activated STAT4 to the promoter of twist1.
Neg (cannot) Positive_regulation (induce) of Transcription (transcription) of twist1
3) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.19 Pain Relevance 0.10
Twist1-specific shRNA reduced the level of activation-induced endogenous twist1 transcripts in Th1 cells to ?
Positive_regulation (induced) of Transcription (transcripts) of twist1 in Th1 cells
4) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.54 Pain Relevance 0.25
Differentiation into beating EBs was accompanied by mesodermal differentiation and dramatic activation of TWIST1, TBX5, and MEOX transcription, as well as the very clear induction of nearly all of the early cardiogenic genes, including FOXC1, ISL2, HAND1, GATA4, 5, and 6, FOXH1, and MEF2C.
Positive_regulation (activation) of Transcription (transcription) of TWIST1 in cardiogenic
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0
There was a correlation between increases in PDE 4D mRNA expression and airway hyper-responsiveness (Deng et al 2006).


Positive_regulation (increases) of Transcription (expression) of PDE
6) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.56 Pain Relevance 0.11
In a murine model, oral administration of ciclamilast dose-dependently inhibited changes in lung resistance and lung dynamic compliance, up-regulated cAMP-PDE activity, and increased PDE 4D, but not PDE 4B, mRNA expression in lung tissue.
Neg (not) Positive_regulation (increased) of Transcription (expression) of PDE in lung
7) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.64 Pain Relevance 0.15

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