INT243621

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.08
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 3
Th17 cells 1
colon 1
lung 1
cardiogenic 1
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 556 98.08 Very High Very High Very High
Crohn's disease 63 96.04 Very High Very High Very High
cytokine 229 95.36 Very High Very High Very High
rheumatoid arthritis 38 90.56 High High
Arthritis 135 88.60 High High
Bioavailability 4 51.36 Quite High
Inflammatory response 47 37.44 Quite Low
chemokine 42 12.56 Low Low
adenocard 8 12.56 Low Low
imagery 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 604 98.08 Very High Very High Very High
Inflammatory Bowel Disease 74 96.28 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 108 96.20 Very High Very High Very High
Disease 169 96.04 Very High Very High Very High
Rheumatoid Arthritis 56 90.56 High High
Arthritis 117 88.60 High High
Severe Combined Immunodeficiency 40 88.48 High High
Hypersensitivity 133 87.40 High High
Asthma 105 83.56 Quite High
Pulmonary Disease 217 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B are required, but not sufficient, to induce transcription of twist1 in Th cells.
Transcription (transcription) of twist1
1) Confidence 0.71 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Of all costimulatory signals involved in the lineage differentiation of murine Th1, Th2, or Th17 cells, only IL-12 was able to induce transcription of twist1.
Transcription (transcription) of twist1 in Th17 cells
2) Confidence 0.68 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.11 Pain Relevance 0.06
B cannot induce transcription of twist1 on their own, but require concerted binding of activated STAT4 to the promoter of twist1.
Transcription (transcription) of twist1
3) Confidence 0.68 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.19 Pain Relevance 0.10
B inhibitor pyrrolidine dithiocarbamate (20), the NFAT-specific inhibitory 3,5-bistrifluoromethyl pyrazole derivative BTP1 (21), and the calcineurin-inhibitor cyclosporine A (22) all blocked the PMA/ionomycin-induced expression of twist1 mRNA (Fig. 3 B), showing that both NFAT and NF-?
Transcription (expression) of twist1
4) Confidence 0.68 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
S2 displays the result of ectopic T-bet expression on twist1 mRNA induction, as well as an immunoblot to confirm T-bet overexpression.
Transcription (induction) of twist1
5) Confidence 0.53 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.18 Pain Relevance 0.18
Twist1 mRNA expression in resting Th1 cells correlated with their age in vitro and the number of restimulations they had experienced.
Transcription (expression) of Twist1 in Th1 cells
6) Confidence 0.53 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.34 Pain Relevance 0.08
Twist1-specific shRNA reduced the level of activation-induced endogenous twist1 transcripts in Th1 cells to ?
Transcription (transcripts) of twist1 in Th1 cells
7) Confidence 0.53 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.54 Pain Relevance 0.25
Repeated biopsies from individual patients show persistent twist1 mRNA levels over time, i.e., the persistence of chronically reactivated Th1 cells, despite state-of-the-art therapeutic treatment.
Transcription (levels) of twist1 in Th1 cells
8) Confidence 0.53 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.10 Pain Relevance 0.05
Twist1 mRNA expression in repeatedly sampled patients with persistent inflammation of colon or synovia remained in the same range over up to 18 mo (Table S2).
Transcription (expression) of Twist1 in colon associated with inflammation
9) Confidence 0.53 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.54 Pain Relevance 0.18
Differentiation into beating EBs was accompanied by mesodermal differentiation and dramatic activation of TWIST1, TBX5, and MEOX transcription, as well as the very clear induction of nearly all of the early cardiogenic genes, including FOXC1, ISL2, HAND1, GATA4, 5, and 6, FOXH1, and MEF2C.
Transcription (transcription) of TWIST1 in cardiogenic
10) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0
In a murine model, oral administration of ciclamilast dose-dependently inhibited changes in lung resistance and lung dynamic compliance, up-regulated cAMP-PDE activity, and increased PDE 4D, but not PDE 4B, mRNA expression in lung tissue.
Transcription (expression) of PDE in lung
11) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.58 Pain Relevance 0.14
There was a correlation between increases in PDE 4D mRNA expression and airway hyper-responsiveness (Deng et al 2006).


Transcription (expression) of PDE
12) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.56 Pain Relevance 0.10
Theophylline is often described as a phosphodiesterase (PDE) inhibitor but is also known to have many “off-target” interactions including gene regulation.100 Importantly, the concentrations that can achieve this GC sparing are below the concentration at which it targets PDE.
Transcription (described) of PDE
13) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.78 Pain Relevance 0.09

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