INT243641

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Twist1, Socs1) cell differentiation (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Twist1 (Mus musculus)
Socs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 23 100.00 Very High Very High Very High
chemokine 4 100.00 Very High Very High Very High
Inflammation 41 69.44 Quite High
Arthritis 15 36.24 Quite Low
Crohn's disease 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 69.44 Quite High
Hypersensitivity 14 50.00 Quite Low
Arthritis 13 36.24 Quite Low
Severe Combined Immunodeficiency 4 29.60 Quite Low
Disease 14 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 8 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 2 5.00 Very Low Very Low Very Low
Rheumatic Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from cytokine expression, twist1 also decreases expression of proinflammatory chemokines and chemokine receptors, and attenuates cytokine receptor signaling by up-regulating SOCS-1 and -2, the IL-1 decoy receptor, and by down-regulating Jak2, the kinase involved in IL-12 signaling.
twist1 Positive_regulation (up-regulating) of SOCS-1 associated with chemokine and cytokine
1) Confidence 0.14 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.13 Pain Relevance 0.31

General Comments

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