INT243668

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.94
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
neurons 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 4 91.20 High High
Inflammation 60 80.84 Quite High
cytokine 59 79.76 Quite High
Inflammatory response 4 50.48 Quite High
Arthritis 8 33.36 Quite Low
Central nervous system 2 30.32 Quite Low
Sciatic nerve 17 17.88 Low Low
Spinal cord 34 5.00 Very Low Very Low Very Low
Multiple sclerosis 22 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 22 99.70 Very High Very High Very High
Obesity 20 94.28 High High
Insulin Resistance 20 81.76 Quite High
INFLAMMATION 68 80.84 Quite High
Sepsis 63 76.24 Quite High
Experimental Arthritis 8 33.36 Quite Low
Multiple Sclerosis 34 22.64 Low Low
Adhesions 7 16.04 Low Low
Inflammatory Bowel Disease 14 7.60 Low Low
Stress 14 6.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in our case statistically insignificant reduction of p-JNK concentration in cells could result in significant down-regulation of Jun phosphorylation.
Negative_regulation (down) of Phosphorylation (phosphorylation) of Jun
1) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09
Thus, in our case statistically insignificant reduction of p-JNK concentration in cells could result in significant down-regulation of Jun phosphorylation.
Negative_regulation (regulation) of Phosphorylation (phosphorylation) of Jun
2) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09
JNK activation was determined by monitoring phosphorylation of JNK (Thr183 and Tyr185) and c-Jun (Ser63), which is a substrate of JNK.
Negative_regulation (monitoring) of Phosphorylation (phosphorylation) of c-Jun
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.84 Pain Relevance 0.12
ATF3 is a member of the CREB family and its rapid expression after injury in neurons is preceded by a fast upregulation of JNK and phophorylation of c-jun [12,13,16].
Negative_regulation (preceded) of Phosphorylation (phophorylation) of c-jun in neurons associated with injury
4) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.10 Pain Relevance 0

General Comments

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