INT243674

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.05
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 12
Mp (Mus musculus)
IL-17 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 161 93.92 High High
Potency 14 64.52 Quite High
Spinal cord 84 54.48 Quite High
Inflammation 91 52.64 Quite High
dexamethasone 14 44.40 Quite Low
Multiple sclerosis 77 21.64 Low Low
rheumatoid arthritis 35 5.00 Very Low Very Low Very Low
Arthritis 28 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 91 52.64 Quite High
Asthma 14 48.24 Quite Low
Disease 35 46.00 Quite Low
Multiple Sclerosis 119 43.48 Quite Low
Autoimmune Disease 91 35.12 Quite Low
Inflammatory Bowel Disease 49 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 35 5.00 Very Low Very Low Very Low
Experimental Arthritis 28 5.00 Very Low Very Low Very Low
Leukemia 21 5.00 Very Low Very Low Very Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the result, MP inhibited IL-17 generation in purified T lymphocytes, but less efficiently than in LNC (Fig 3A, B), thus suggesting that MP affected IL-17 production in LNC through direct influence on T cells and indirect influence on accessory cells.
MP Regulation (affected) of Gene_expression (production) of IL-17 in T cells
1) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.06
As a result it was shown that MP potently inhibited IL-6 production in LPS-stimulated CD3- cells, thus suggesting that indirect influence of MP on IL-17 production could be, at least partly, conducted through inhibition of IL-6 production by non-T cells.


MP Regulation (influence) of Gene_expression (production) of IL-17 in T cells
2) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05
In order to explore indirect influence of MP on IL-17 production, which could be important for the observed difference in efficiency of MP in inhibition of IL-17 in purified T cells and LNC, CD3- cells were stimulated with LPS in the presence or absence of MP and production of a major IL-17-promoting cytokine – IL-6 was determined.
MP Regulation (influence) of Gene_expression (production) of IL-17 in T cells associated with cytokine
3) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05
Similarly to results obtained in LNC the effect of MP on IL-17 production by purified T lymphocytes was weaker than its influence on IFN-?
MP Regulation (effect) of Gene_expression (production) of IL-17 in T lymphocytes
4) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.06
It is thus expected that MP affects IL-17 production in LNC more potently than in purified T cells.
MP Regulation (affects) of Gene_expression (production) of IL-17 in T cells
5) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.08
inhibition was similar in LNC and purified T cells, contrary to the difference observed in the effect of MP on IL-17 production by LNC and purified T cells (Fig 3A–D).
MP Regulation (effect) of Gene_expression (production) of IL-17 in T cells
6) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
Accordingly, inhibitors of all of the three MAPKs collaborated with MP in its action against IL-17 generation, thus suggesting that MP did not use any of the signaling routes for its effect on IL-17 production.
MP Regulation (effect) of Gene_expression (production) of IL-17
7) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox