INT24371

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.37
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sphk1) plasma membrane (Sphk1) nucleus (Sphk1)
DNA binding (Sphk1) cytoplasm (Sphk1)
Sphk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 91.00 High High
gABA 3 80.56 Quite High
Hippocampus 3 75.00 Quite High
antagonist 1 73.52 Quite High
Inflammatory response 8 71.00 Quite High
Pyramidal cell 1 62.88 Quite High
Central nervous system 2 22.76 Low Low
Spinal cord 2 20.84 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 62 97.04 Very High Very High Very High
Parkinson's Disease 2 85.84 High High
Optic Nerve Injuries 68 81.48 Quite High
INFLAMMATION 14 70.64 Quite High
Shock 2 67.40 Quite High
Injury 64 63.48 Quite High
Stress 4 62.72 Quite High
Death 102 62.24 Quite High
Retina Disease 8 43.04 Quite Low
Necrosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atropine (50-100 mg/kg, i.p.) did not change greatly SPK activity or its behavioral correlation.
Neg (not) Positive_regulation (change) of SPK
1) Confidence 0.41 Published 1988 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2455634 Disease Relevance 0 Pain Relevance 0.34
Our array study reveals that the RNA of some enzymes linked to sphingosine metabolism are soon upregulated after IONT (Sphk1 and Sgpl1) and after IONC (Sphk1 and 2) [58-60].
Positive_regulation (upregulated) of Sphk1
2) Confidence 0.32 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.18 Pain Relevance 0.06
Our array study reveals that the RNA of some enzymes linked to sphingosine metabolism are soon upregulated after IONT (Sphk1 and Sgpl1) and after IONC (Sphk1 and 2) [58-60].
Positive_regulation (upregulated) of Sphk1
3) Confidence 0.30 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.19 Pain Relevance 0.06

General Comments

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