INT243711

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park7) mitochondrion organization (Park7) response to stress (Park7)
cytoplasm (Park7) cell proliferation (Park7) cytosol (Park7)
Anatomy Link Frequency
neurons 1
nucleus 1
Park7 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 3 70.76 Quite High
ischemia 1 52.00 Quite High
midbrain 28 21.36 Low Low
Dopamine 12 12.96 Low Low
Glutamate 12 5.00 Very Low Very Low Very Low
Neuropathic pain 9 5.00 Very Low Very Low Very Low
Calcium channel 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
sodium channel 7 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 180 99.36 Very High Very High Very High
Stress 31 97.16 Very High Very High Very High
Apoptosis 10 97.00 Very High Very High Very High
Neuroma 79 91.48 High High
Nervous System Injury 11 83.52 Quite High
Necrosis 3 76.52 Quite High
Cancer 4 76.16 Quite High
Parkinson's Disease 92 75.60 Quite High
Death 20 59.44 Quite High
Hypoxia 1 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the formation of the ubiquitin E3 ligase activity complex (by PINK1, DJ-1 and parkin) seems to have a neuroprotective role in mitochondria-mediated apoptosis (Darios et al., 2003; Petit et al., 2005; Gorner et al., 2007).
DJ-1 Binding (formation) of associated with apoptosis
1) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.60 Pain Relevance 0.04
The protective role of DJ-1 has been mostly associated to its ability to translocate to the mitochondria and nucleus where it can exert antioxidant and transcriptional modulatory actions (Zhang et al., 2005).
DJ-1 Binding (associated) of in nucleus
2) Confidence 0.20 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.20 Pain Relevance 0
Recently, DJ-1 was associated with Parkinson's disease and the protection of neurons from oxidative stress [28].
DJ-1 Binding (associated) of in neurons associated with stress and disease
3) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.69 Pain Relevance 0.03

General Comments

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