INT243712

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.68
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
neurons 2
whiskers 2
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 98.80 Very High Very High Very High
GABA receptor 2 98.64 Very High Very High Very High
GABAergic 49 96.68 Very High Very High Very High
Glutamate 5 96.04 Very High Very High Very High
Neurotransmitter 1 90.92 High High
medulla 7 50.04 Quite High
rheumatoid arthritis 3 40.88 Quite Low
nMDA receptor 4 40.64 Quite Low
Somatosensory cortex 1 40.36 Quite Low
Locus ceruleus 8 36.40 Quite Low
Disease Link Frequency Relevance Heat
Neuroma 79 100.00 Very High Very High Very High
Generalized Anxiety Disorder 42 100.00 Very High Very High Very High
Targeted Disruption 1 99.10 Very High Very High Very High
Sleep Disorders 13 98.28 Very High Very High Very High
Epilepsy 4 94.80 High High
Autoimmune Disease 67 89.92 High High
Syndrome 78 87.04 High High
Parkinson's Disease 1 87.04 High High
Convulsion 42 86.32 High High
Disease 7 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calpain small subunit 1 displayed increased expression in the neuromas, whilst guanine nucleotide-binding protein Go subunit alpha 2, ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1), gamma-synuclein, mimecan precursor were all down-regulated (Table 2).
Positive_regulation (increased) of Gene_expression (expression) of ubiquitin carboxyl-terminal hydrolase isozyme L1 associated with neuroma
1) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.57 Pain Relevance 0
After PS recovery, a large number of Fos+/GAD+ neurons was observed in the vlPAG and to a minor extent the dlPAG, dmPAG and the lPAG.
Positive_regulation (observed) of Gene_expression (neurons) of GAD in neurons associated with generalized anxiety disorder
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.46 Pain Relevance 0.24
There is a lower expression of GABA receptors in the fragile X knock out (KO) mouse (DÂ’Hulst et al. 2006) and an increased expression of glutamic acid decarboxylase (GAD), the enzyme responsible for GABA synthesis in the KO mouse (El Idrissi et al. 2005).
Positive_regulation (increased) of Gene_expression (expression) of GAD associated with targeted disruption, gaba, generalized anxiety disorder and gaba receptor
3) Confidence 0.06 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.54 Pain Relevance 0.21
One indicator of an acute potentiation of inhibition is the increased expression of GAD in barrels corresponding to the principal whiskers after a few days of stimulation (Welker et al., 1989).
Positive_regulation (increased) of Gene_expression (expression) of GAD in whiskers associated with generalized anxiety disorder
4) Confidence 0.01 Published 2006 Journal Neuroscience Section Body Doc Link PMC2860223 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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