INT243713

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 1 22.72 Low Low
Neuropathic pain 9 5.00 Very Low Very Low Very Low
Calcium channel 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 7 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
nav1.3 6 5.00 Very Low Very Low Very Low
nav1.8 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroma 79 100.00 Very High Very High Very High
Precocious Puberty 38 98.88 Very High Very High Very High
Polyostotic Fibrous Dysplasia 9 94.80 High High
Epilepsy 1 94.80 High High
Disease 5 92.36 High High
Granulosa Cell Tumor 4 88.72 High High
Ovarian Cysts 36 85.12 High High
Parkinson's Disease 1 81.52 Quite High
Hypogonadotropic Hypogonadism 1 79.60 Quite High
Reprotox - General 1 18 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is due to post-zygotic-activating recurrent mutations in the guanine-nucleotide-binding protein (G protein) ?
Positive_regulation (activating) of Gene_expression (mutations) of guanine-nucleotide-binding protein
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 2.07 Pain Relevance 0
Calpain small subunit 1 displayed increased expression in the neuromas, whilst guanine nucleotide-binding protein Go subunit alpha 2, ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1), gamma-synuclein, mimecan precursor were all down-regulated (Table 2).
Positive_regulation (increased) of Gene_expression (expression) of guanine nucleotide-binding protein associated with neuroma
2) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.51 Pain Relevance 0

General Comments

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