INT24372

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sphk1) plasma membrane (Sphk1) nucleus (Sphk1)
DNA binding (Sphk1) cytoplasm (Sphk1)
Sphk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 99.02 Very High Very High Very High
gABA 9 93.52 High High
Hippocampus 9 87.20 High High
antagonist 3 86.48 High High
Pyramidal cell 3 75.84 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diazepam (5-10 mg/kg, i.p.) increased amplitude and decreased frequency of hippocampal fast EEG activity, and reduced SPK activity.
Negative_regulation (reduced) of SPK
1) Confidence 0.59 Published 1988 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2455634 Disease Relevance 0 Pain Relevance 0.39
Three general anesthetics (ether, urethane and pentobarbital) all reduced SPK activity.
Negative_regulation (reduced) of SPK
2) Confidence 0.59 Published 1988 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2455634 Disease Relevance 0 Pain Relevance 0.20
This SPK abolition during anesthesia seemed qualitatively different from RSA-related SPK suppression in undrugged animals in that unlike the latter case RSA generation was not the cause of SPK abolition in the former case.
Negative_regulation (suppression) of SPK associated with anesthesia
3) Confidence 0.38 Published 1988 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2455634 Disease Relevance 0 Pain Relevance 0.27

General Comments

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