INT24373

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sphk1) plasma membrane (Sphk1) nucleus (Sphk1)
DNA binding (Sphk1) cytoplasm (Sphk1)
Sphk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 99.02 Very High Very High Very High
Hippocampus 6 79.88 Quite High
fortral 2 77.84 Quite High
gABA 6 74.40 Quite High
antagonist 2 67.36 Quite High
Pyramidal cell 2 56.72 Quite High
cocaine 1 53.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This SPK abolition during anesthesia seemed qualitatively different from RSA-related SPK suppression in undrugged animals in that unlike the latter case RSA generation was not the cause of SPK abolition in the former case.
Gene_expression (abolition) of SPK associated with anesthesia
1) Confidence 0.67 Published 1988 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2455634 Disease Relevance 0 Pain Relevance 0.31
This SPK abolition during anesthesia seemed qualitatively different from RSA-related SPK suppression in undrugged animals in that unlike the latter case RSA generation was not the cause of SPK abolition in the former case.
Gene_expression (suppression) of SPK associated with anesthesia
2) Confidence 0.59 Published 1988 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 2455634 Disease Relevance 0 Pain Relevance 0.27
We have successfully reconstituted this hypothetical model in HEK-293 cells overexpressing both the sigma1 receptor and sphingosine kinase-1.
Gene_expression (overexpressing) of sphingosine kinase-1
3) Confidence 0.01 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.10

General Comments

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