INT243751

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
nucleus 1
forebrain 1
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 96.12 Very High Very High Very High
Central nervous system 4 95.20 Very High Very High Very High
Pyramidal cell 2 86.96 High High
medulla 2 85.20 High High
amygdala 4 82.56 Quite High
long-term potentiation 16 29.48 Quite Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 4 95.36 Very High Very High Very High
Targeted Disruption 18 86.72 High High
Peripheral Neuropathy 6 45.60 Quite Low
Neuropathic Pain 2 40.64 Quite Low
Charcot Marie Tooth Disease 4 39.68 Quite Low
Disease 2 37.52 Quite Low
Syndrome 2 35.28 Quite Low
Appetite Loss 16 33.60 Quite Low
Anxiety Disorder 40 31.12 Quite Low
Cognitive Disorder 40 15.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCR and Western blotting established evidence for efficient forebrain deletion of Egr2.
Localization (deletion) of Egr2 in forebrain
1) Confidence 0.75 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.18 Pain Relevance 0.08
In contrast to Egr1 and Egr3, Egr2 protein has been detected in both the nucleus and cytoplasm of forebrain neurons (De et al., 2003; Mack et al., 1992).
Localization (detected) of Egr2 in nucleus
2) Confidence 0.75 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.26

General Comments

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