INT243756

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.18
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
neural 12
macrophage 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 88.16 High High
rheumatoid arthritis 11 75.28 Quite High
Hippocampus 60 55.76 Quite High
long-term potentiation 48 51.12 Quite High
endometriosis 1 42.00 Quite Low
pain pelvic 1 38.96 Quite Low
Inflammation 5 20.56 Low Low
psoriasis 2 16.40 Low Low
Central nervous system 12 5.00 Very Low Very Low Very Low
opiate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 12 100.00 Very High Very High Very High
Autoimmune Disease 16 98.36 Very High Very High Very High
Vasculitis 88 90.68 High High
INFLAMMATION 5 87.76 High High
Hypoxia 2 83.96 Quite High
Stress 3 83.20 Quite High
Rheumatoid Arthritis 11 75.28 Quite High
Endometriosis (extended) 1 42.00 Quite Low
Reprotox - General 3 2 38.96 Quite Low
Aging 2 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Positive_regulation (named) of Zif268 in neural
1) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Positive_regulation (named) of Egr1 in neural
2) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Positive_regulation (named) of TIS8 in neural
3) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Positive_regulation (named) of Krox24 in neural
4) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Positive_regulation (named) of immediate early growth response-1 in neural
5) Confidence 0.44 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
Amongst the activity regulated transcription factors, the immediate early growth response-1 gene Egr1 (also named Zif268, Krox24, NGFI-A and TIS8 or the avian homolog Zenk), a member of the Egr family of transcriptional regulators, is one of the best characterised for its role in neural plasticity and memory formation (Davis et al., 2003; Knapska and Kaczmarek, 2004; O'Donovan et al., 1999 for reviews).
Regulation (regulators) of Positive_regulation (named) of Zenk in neural
6) Confidence 0.39 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
For example, we showed previously that EGR1 is markedly upregulated in the PBMCs of SLE patients.4 It also plays a critical role in promoting cellular differentiation along a macrophage lineage.10 Nonetheless, EGR1-null mice are viable and develop and grow normally.19 Rigorous analyses will be needed to determine whether the upregulation of EGR1 mRNA in many vasculitis patients is pathogenically significant or merely an associated phenomenon.
Regulation (role) of Positive_regulation (upregulated) of EGR1 in macrophage associated with vasculitis and systemic lupus erythematosus
7) Confidence 0.25 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.18 Pain Relevance 0.08

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