INT24376

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Context Info
Confidence 0.02
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc12a7)
Anatomy Link Frequency
plasma 2
Slc12a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
Enkephalin 20 99.98 Very High Very High Very High
agonist 9 99.74 Very High Very High Very High
Cannabinoid receptor 3 99.58 Very High Very High Very High
opiate 10 93.88 High High
antagonist 2 92.00 High High
potassium channel 1 59.28 Quite High
tetrodotoxin 1 35.76 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methionine enkephalin (1 microM) or [D-Pen2, D-Pen5]enkephalin inhibited KCl-stimulated amylase release by 32 +/- 4 and 45 +/- 4%, respectively.
Negative_regulation (inhibited) of Localization (release) of KCl-stimulated associated with enkephalin
1) Confidence 0.02 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2455787 Disease Relevance 0 Pain Relevance 1.35
Pretreatment with 1 microM atropine inhibited completely the KCl-stimulated amylase release, suggesting stimulation via a cholinergic pathway.
Negative_regulation (inhibited) of Localization (release) of KCl-stimulated
2) Confidence 0.02 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2455787 Disease Relevance 0 Pain Relevance 0.94
In cerebrocortical nerve terminals, the cannabinoid receptor agonist WIN55,212-2 reduced KCl-evoked glutamate release through a mechanism that restricted the rise of cytoplasmic free Ca2+, but not the changes in plasma membrane depolarization.
Negative_regulation (reduced) of Localization (release) of KCl in plasma associated with glutamate, cannabinoid receptor and agonist
3) Confidence 0.00 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15755482 Disease Relevance 0 Pain Relevance 0.39

General Comments

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