INT243761

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
brain 2
NFAT 2
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 8 98.96 Very High Very High Very High
withdrawal 2 96.84 Very High Very High Very High
opiate 2 96.62 Very High Very High Very High
dopamine receptor 2 96.18 Very High Very High Very High
Hippocampus 10 75.24 Quite High
unmyelinated 2 58.44 Quite High
nav1.8 1 43.16 Quite Low
Peripheral nervous system 2 43.12 Quite Low
c fibre 1 42.60 Quite Low
Central nervous system 3 31.76 Quite Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 2 95.44 Very High Very High Very High
Convulsion 4 94.10 High High
Shock 20 93.76 High High
Anxiety Disorder 20 64.08 Quite High
Cognitive Disorder 20 51.84 Quite High
Appetite Loss 8 33.76 Quite Low
Demyelinating Disease 7 25.16 Quite Low
Attention Deficit Hyperactivity Disorder 1 15.44 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like other Egr members, Egr2 can be induced in brain by various stimuli, including electroconvulsive shock inducing seizure activity (Bhat et al., 1992, this study), focal cerebral ischaemia (An et al., 1992), dopamine receptor activation and opiate withdrawal (Bhat et al., 1992) and in hippocampal neurons following kainic acid injection (Gass et al., 1994) or LTP-inducing stimuli (Williams et al., 1995), although Egr2 is less robustly induced and is not induced by weaker patterns of stimuli despite induction of long-lasting LTP along with Egr1 expression (Worley et al., 1993).
Neg (not) Positive_regulation (induced) of Neg (not) Positive_regulation (induced) of Egr2 in brain associated with brain hemorrhage, convulsion, dopamine receptor, shock, long-term potentiation, opiate and withdrawal
1) Confidence 0.47 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.47 Pain Relevance 0.33
Furthermore, NFAT c4 complexes with Sox-10, a transcription factor required for myelination [17], to activate the promoter and myelin-specific enhancer of the Krox-20 gene, which globally regulates peripheral myelination [11,18-20], and also with the promoter of the myelin protein zero (P0) gene, all of which underline the involvement of NFAT proteins in myelination.
Positive_regulation (required) of Positive_regulation (activate) of Krox-20 in NFAT
2) Confidence 0.39 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.03

General Comments

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