INT243767

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2, Nab1) intracellular (Egr2) DNA binding (Egr2)
transcription factor binding (Nab1) ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
Schwann cells 2
Egr2 (Mus musculus)
Nab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 10 10.20 Low Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 82.68 Quite High
Cognitive Disorder 20 33.24 Quite Low
Anxiety Disorder 20 5.00 Very Low Very Low Very Low
Shock 20 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Appetite Loss 8 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 3 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this, Egr2 was shown to positively regulate the expression of Nab1 and Nab2 in the developing hindbrain (Mechta-Grigoriou et al., 2000, Desmazières, Charnay and Gilardi-Hebenstreit, unpublished data), and a gene expression profiling study in Schwann cells has identified Nab2 as a target of Egr2 (Nagarajan et al., 2001).
Egr2 Regulation (regulate) of Gene_expression (expression) of Nab1 in Schwann cells
1) Confidence 0.63 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.14 Pain Relevance 0

General Comments

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