INT24377

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Context Info
Confidence 0.06
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc12a7)
Anatomy Link Frequency
plasma 1
nerves 1
Slc12a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
Neuropeptide 1 99.98 Very High Very High Very High
Enkephalin 30 99.78 Very High Very High Very High
agonist 14 99.76 Very High Very High Very High
Cannabinoid receptor 3 99.42 Very High Very High Very High
qutenza 1 94.48 High High
opiate 15 93.28 High High
Calcium channel 7 93.04 High High
antagonist 3 92.00 High High
potassium channel 1 59.28 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we have re-addressed this problem and, to eliminate any possible contribution of sensory neuropeptides released by KCl from peripheral endings of afferent nerves, all experiments were performed in ureters pre-exposed to the sensory neurone blocking agent, capsaicin (10 microM for 15 min). 2.
Localization (released) of KCl in nerves associated with qutenza and neuropeptide
1) Confidence 0.06 Published 1995 Journal J Auton Pharmacol Section Abstract Doc Link 7538137 Disease Relevance 0 Pain Relevance 0.34
Pretreatment with 1 microM atropine inhibited completely the KCl-stimulated amylase release, suggesting stimulation via a cholinergic pathway.
Localization (release) of KCl-stimulated
2) Confidence 0.04 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2455787 Disease Relevance 0 Pain Relevance 0.94
Methionine enkephalin (1 microM) or [D-Pen2, D-Pen5]enkephalin inhibited KCl-stimulated amylase release by 32 +/- 4 and 45 +/- 4%, respectively.
Localization (release) of KCl-stimulated associated with enkephalin
3) Confidence 0.04 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2455787 Disease Relevance 0 Pain Relevance 1.34
Addition of methionine enkephalin or 2-D-penicillamine-5-D-penicillamine-enkephalin [( D-Pen2, D-Pen5]enkephalin, a specific delta receptor agonist) inhibited KCl-stimulated amylase release in a dose-dependent fashion.
Localization (release) of KCl-stimulated associated with agonist and enkephalin
4) Confidence 0.03 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2455787 Disease Relevance 0 Pain Relevance 1.25
In cerebrocortical nerve terminals, the cannabinoid receptor agonist WIN55,212-2 reduced KCl-evoked glutamate release through a mechanism that restricted the rise of cytoplasmic free Ca2+, but not the changes in plasma membrane depolarization.
Localization (release) of KCl in plasma associated with glutamate, cannabinoid receptor and agonist
5) Confidence 0.00 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15755482 Disease Relevance 0 Pain Relevance 0.39

General Comments

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