INT243771

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.77
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (Safb) RNA binding (Safb) nucleus (Safb)
DNA binding (Safb)
Anatomy Link Frequency
myotubes 3
synapses 1
Safb (Mus musculus)
Safb - Y522S (1) Safb - R163C (1)
Pain Link Frequency Relevance Heat
GABAergic 32 99.12 Very High Very High Very High
amygdala 120 98.92 Very High Very High Very High
gABA 48 98.48 Very High Very High Very High
addiction 72 93.24 High High
Hippocampus 6 86.84 High High
withdrawal 9 71.84 Quite High
agonist 25 40.48 Quite Low
halothane 12 7.84 Low Low
antagonist 5 7.64 Low Low
alcohol 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 63 91.60 High High
Malignant Hyperthermia 75 90.68 High High
Cognitive Disorder 5 78.88 Quite High
Shock 7 24.28 Low Low
Contracture 10 6.40 Low Low
Alcohol Addiction 16 5.00 Very Low Very Low Very Low
Immunization 13 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to analyze the effect of HET on IgA immune response against intestinal antigen, HET was administered to mice at a dose of 1000 mg kg?
Negative_regulation (administered) of HET
1) Confidence 0.26 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0 Pain Relevance 0
A major question for future studies therefore will be whether GluR1 HET are similarly impaired on other tasks requiring rapid and memory formation.


Spec (whether) Negative_regulation (impaired) of HET
2) Confidence 0.24 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.60 Pain Relevance 0.04
These reductions in maximal current density for Het and Hom myotubes were proportional to the respective reductions in Qmax (see Fig. 2 D), as indicated by the nearly identical Gmax/Qmax ratios (Table II).
Negative_regulation (reductions) of Het in myotubes
3) Confidence 0.13 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0
10% reduction in Qmax in Y522S Het interosseus fibers.
Negative_regulation (reduction) of Het (Y522S)
4) Confidence 0.11 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.08 Pain Relevance 0.11
First, as shown in Fig. 3 B, peak current amplitudes in Het (?
Negative_regulation (amplitudes) of Het
5) Confidence 0.11 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0
One of the major features observed in the K+ depolarization experiments is that the inactivation of ECC during prolonged depolarization was slowed in R163C Het and Hom myotubes (Figs. 1 and 7 of Estève et al., 2010).
Negative_regulation (slowed) of Het (R163C) in myotubes
6) Confidence 0.11 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0.05
The magnitude of the charge movements was reduced in both Het and Hom myotubes (Qmax = 7.4 ± 1.0 nC/µF; n = 7, and 6.4 ± 0.7 nC/µF; n = 7, respectively) compared with WT myotubes (9.9 ± 1.1 nC/µF; n = 7), although this reduction was significant only for Hom (P < 0.05 by t test; Table II).
Negative_regulation (reduced) of Het in myotubes
7) Confidence 0.11 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.09 Pain Relevance 0.11
Therefore, using an in vitro electrophysiological approach in brain slices, here we have investigated a possible role of the AC7 signaling pathway in ethanol and CRF effects on CeA GABAergic synapses of genetically modified mice with diminished brain Adcy7 activity (HET) compared to their littermate male wild-type (WT) mice.
Negative_regulation (diminished) of HET in synapses associated with gabaergic and amygdala
8) Confidence 0.09 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.55
However, these effects were absent in HET mice.
Negative_regulation (absent) of HET
9) Confidence 0.09 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.37

General Comments

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