INT243779

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.62
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Isl1) intracellular (Isl1) DNA binding (Isl1)
Anatomy Link Frequency
B cells 3
telencephalic 2
macrophages 1
Isl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 98 100.00 Very High Very High Very High
cytokine 68 100.00 Very High Very High Very High
gABA 34 99.92 Very High Very High Very High
Nucleus accumbens 1 86.84 High High
amygdala 33 84.16 Quite High
agonist 14 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
GABAergic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 98 100.00 Very High Very High Very High
Death 44 99.96 Very High Very High Very High
Diabetes Mellitus 250 97.76 Very High Very High Very High
Hyperglycemia 2 69.20 Quite High
Stress 18 65.16 Quite High
Infection 2 47.80 Quite Low
Weight Gain 4 46.52 Quite Low
Toxicity 10 43.60 Quite Low
Apoptosis 30 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regional markers: telencephalic expression of NOS, Isl1, GABA, and Nkx2.1
Negative_regulation (markers) of Gene_expression (expression) of Isl1 in telencephalic associated with gaba
1) Confidence 0.30 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.20
This protection is vested in significant reduction of islet-reactive T cells, restoration of the sensitivity of T and B cells to AICD, suppression of islet-toxic pro-inflammatory cytokine production in primary T and B cells and macrophages isolated from NOD mice, and preservation of a key anti-inflammatory cytokine, IL-10.
Negative_regulation (suppression) of Gene_expression (production) of islet-toxic in B cells associated with inflammation, diabetes mellitus, death and cytokine
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 1.31 Pain Relevance 0.24
This protection is vested in significant reduction of islet-reactive T cells, restoration of the sensitivity of T and B cells to AICD, suppression of islet-toxic pro-inflammatory cytokine production in primary T and B cells and macrophages isolated from NOD mice, and preservation of a key anti-inflammatory cytokine, IL-10.
Negative_regulation (suppression) of in macrophages Gene_expression (production) of islet-toxic in B cells associated with inflammation, diabetes mellitus, death and cytokine
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 1.31 Pain Relevance 0.24

General Comments

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