INT243793

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.74
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 3 75.80 Quite High
Ventral tegmentum 1 61.88 Quite High
cytokine 5 61.68 Quite High
Substantia nigra 9 57.92 Quite High
midbrain 11 50.00 Quite Low
Dopamine 3 49.72 Quite Low
carbamazepine 2 45.44 Quite Low
Glutamate 3 44.88 Quite Low
Potency 2 23.20 Low Low
aspirin 2 6.60 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 54 100.00 Very High Very High Very High
Adhesions 4 100.00 Very High Very High Very High
Cancer 146 96.90 Very High Very High Very High
Repression 2 94.28 High High
Fibrosarcoma 8 91.60 High High
Obesity 79 84.88 Quite High
Aging 1 84.64 Quite High
Metastasis 6 83.32 Quite High
Sarcoma 2 73.04 Quite High
Solid Tumor 3 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In THP1 cells, PI3K phosphorylates Akt, which in its active form is an inhibitor of the NFkappaB and p38 MAP Kinase pathways.
Phosphorylation (phosphorylates) of PI3K
1) Confidence 0.42 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.21 Pain Relevance 0
Arbiser et al. reported that Solenopsin, the alkaloidal component of the fire ant, prevented angiogenesis by inhibiting the activation of PI3K and the phosphorylation of AKT [29].
Phosphorylation (phosphorylation) of PI3K
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.30 Pain Relevance 0.03
In addition, whole genome expression by microarray analysis from primary tumors of VPA-treated patients demonstrate significant up-regulation of hundreds of genes belonging to multiple pathways including ribosomal proteins, oxidative phosphorylation, MAPK signaling, focal adhesion, cell cycle, antigen processing and presentation, proteasome, apoptosis, PI3K, Wnt signaling, calcium signaling, TGF-beta signaling, and ubiquitin-mediated proteolysis, among others [175].
Phosphorylation (phosphorylation) of PI3K associated with cancer, apoptosis and adhesions
3) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.88 Pain Relevance 0.04
PI3K is a master kinase that catalyzes the phosphorylation of PtdIns(4,5)P2 to produce PtdIns(3,4,5)P3.
Phosphorylation (phosphorylation) of PI3K
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Phosphorylated PI3K then activates the Akt-dependent anti-apoptotic pathway, which involves the inactivation of the proapoptotic protein BAD and consequently the repression of the intrinsic pathway (del Peso et al., 1997).
Phosphorylation (Phosphorylated) of PI3K associated with repression and apoptosis
5) Confidence 0.21 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.36 Pain Relevance 0.06

General Comments

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