INT243794

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.61
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FGF20) signal transduction (FGF20) extracellular region (FGF20)
cell-cell signaling (FGF20)
Anatomy Link Frequency
neuronal 1
brain 1
Fibroblast 1
FGF20 (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 36 100.00 Very High Very High Very High
midbrain 44 93.68 High High
Dopamine 12 86.12 High High
Central nervous system 4 64.40 Quite High
monoamine 8 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Neuritis 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Ventral tegmentum 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 91.68 High High
Death 60 78.56 Quite High
Mucocutaneous Lymph Node Syndrome 12 66.48 Quite High
Cancer 4 60.28 Quite High
Infection 4 59.92 Quite High
Reprotox - General 1 4 50.00 Quite Low
Repression 4 34.56 Quite Low
Disease 24 32.88 Quite Low
Apoptosis 36 30.36 Quite Low
Hypokinesia 4 20.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hESC differentiation studies, FGF-20 (PeproTech EC, UK) was added in a concentration of 1?
Gene_expression (added) of FGF-20
1) Confidence 0.62 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.16 Pain Relevance 0
Fibroblast growth factor (FGF)-20 and its receptor are expressed in the substantia nigra and FGF-20 has a preferential neurotrophic activity, including a survival-promoting effect, on dopaminergic neurons (Murase and McKay, 2006; Ohmachi et al., 2000; Ohmachi et al., 2003).
Gene_expression (expressed) of FGF-20 in Fibroblast associated with substantia nigra
2) Confidence 0.62 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.18 Pain Relevance 0.15
In addition, the receptor for FGF-20, FGFR1c, is highly expressed by TH-positive neurons in the substantia nigra and is lower in other brain regions (Ohmachi et al., 2003).
Gene_expression (expressed) of FGF-20 in brain associated with substantia nigra
3) Confidence 0.56 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.20 Pain Relevance 0.10
Regardless of whether FGF-20 had been added or not, 17% of the hESC-derived cells expressed the pan-neuronal marker b-III-Tubulin.
Gene_expression (expressed) of FGF-20 in neuronal
4) Confidence 0.56 Published 2007 Journal Frontiers in Neuroanatomy Section Abstract Doc Link PMC2525922 Disease Relevance 0.08 Pain Relevance 0.20

General Comments

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