INT243799

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 6.63
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
Anatomy Link Frequency
HT-1080 4
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 2 99.56 Very High Very High Very High
cva 8 99.04 Very High Very High Very High
bradykinin 67 98.56 Very High Very High Very High
COX-2 inhibitor 52 94.76 High High
agonist 27 92.08 High High
imagery 11 91.16 High High
Enkephalin 40 85.60 High High
Kinase C 14 82.16 Quite High
Opioid 67 81.12 Quite High
Ventral tegmentum 2 65.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 345 99.56 Very High Very High Very High
Necrosis 6 99.28 Very High Very High Very High
Hemorrhage 5 99.04 Very High Very High Very High
Thrombosis 5 98.44 Very High Very High Very High
Targeted Disruption 5 97.84 Very High Very High Very High
Pancreatic Cancer 74 97.64 Very High Very High Very High
Sarcoma 6 96.52 Very High Very High Very High
Apoptosis 171 96.32 Very High Very High Very High
Fibrosarcoma 40 94.72 High High
Leukemia 10 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although not significant is that - due to broad inter-patient variability-TDF's expressed FAK, PYK and PI3K in higher levels when cultured on PLLA/Col-I blend nanofibers compared to PLLA nanofibers or glass surfaces.
Gene_expression (expressed) of PI3K
1) Confidence 0.45 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0.05 Pain Relevance 0
bp: base pair; EGFR: epidermal growth factor receptor; ERK: extracellular signal-regulated kinase; FC: fold change; HMM: hidden Markov model; IL: interleukin; LOH: loss of heterozygosity; MAPK: mitogen-activated protein kinase; mTOR: mammalian target of rapamycin; PET-CT: positron emission tomography-computed tomography; PI3K: phosphoinositide 3-kinase; PTEN: phosphatase and tensin homolog; SNP: single-nucleotide polymorphism; WTSS: whole transcriptome shotgun sequencing.


Gene_expression (phosphatase) of PI3K associated with positron emission tomography
2) Confidence 0.44 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.38 Pain Relevance 0.05
The phosphoinositide 3-OH kinase (PI3K)/Akt pathway, which is frequently amplified or activated in pancreatic cancer, may also contribute to resistance in several ways including the inhibition of proapoptotic proteins BAD and caspase 9 (Schlieman et al. 2003), dysregulation of the mammalian target of rapamycin (mTOR)-S6K1 signaling pathway (Asano et al. 2005), and activation of the nuclear factor kappa B (NF?
Gene_expression (The) of PI3K associated with pancreatic cancer
3) Confidence 0.43 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012429 Disease Relevance 0.94 Pain Relevance 0
The phosphoinositide 3-OH kinase (PI3K)/Akt pathway, which is frequently amplified or activated in pancreatic cancer, may also contribute to resistance in several ways including the inhibition of proapoptotic proteins BAD and caspase 9 (Schlieman et al. 2003), dysregulation of the mammalian target of rapamycin (mTOR)-S6K1 signaling pathway (Asano et al. 2005), and activation of the nuclear factor kappa B (NF?
Gene_expression (/) of PI3K associated with pancreatic cancer
4) Confidence 0.43 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012429 Disease Relevance 0.92 Pain Relevance 0
However, it would seem more realistic to consider PI3K as an upstream molecule of p38 MAPK and NFkappaB pathways (Figure 7).
Gene_expression (pathways) of PI3K
5) Confidence 0.39 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.20 Pain Relevance 0
As shown in Fig. 5C, PO at 12.5 µg/ml led to the decreased expression of PI3K and phosphorylation of its downstream target AKT.
Gene_expression (expression) of PI3K
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.37 Pain Relevance 0.03
PO downregulated the expression of VEGF and PI3K/AKT signaling in HT-1080 cells
Gene_expression (expression) of PI3K in HT-1080
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.47 Pain Relevance 0.05
Similarly, we also showed that PO reduced the expression of PI3K, subsequently downregulated the phosphorylation of AKT, and VEGF secretion in HT-1080 sarcoma cells.
Gene_expression (expression) of PI3K in HT-1080 associated with sarcoma
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.24 Pain Relevance 0.03
Indeed, when cultured on these nanofiber scaffolds we found an increased expression of FAK, PYK and phosphoinositide 3-kinase (PI3K) gene (figure 6) compared to PLLA scaffolds or cover slip control.
Gene_expression (expression) of PI3K
9) Confidence 0.35 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0 Pain Relevance 0
PO downregulated the expression of VEGF and PI3K/AKT signaling in HT-1080 cells
Gene_expression (expression) of PI3K in HT-1080
10) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.47 Pain Relevance 0.05
To determine the potential involvement of the PI3K pathway in the resensitization response to bradykinin, we applied the PI3K inhibitor LY294002 (50 ?
Gene_expression (pathway) of PI3K associated with bradykinin
11) Confidence 0.30 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.43
Taken together, these results suggest that PO inhibits bFGF-induced angiogenesis in HUVECs and decreased the levels of PI3K, phospho-AKT and VEGF in HT-1080 cells.



Gene_expression (levels) of PI3K in HT-1080
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2925949 Disease Relevance 0.28 Pain Relevance 0.05
PI3K produces PIP3 (phosphatidylinositol 3,4,5 triphosphate) that activates PDK1 (pyruvate deshydrogenase kinase).
Gene_expression (produces) of PI3K
13) Confidence 0.29 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.21 Pain Relevance 0.16
Previously, was shown that FGF-20 treatment results in the phosphorylation phosphoinositide-3 kinase (PI3K) (Murase and McKay, 2006).
Gene_expression (results) of phosphorylation phosphoinositide-3 kinase
14) Confidence 0.17 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.40 Pain Relevance 0.09
Previously, was shown that FGF-20 treatment results in the phosphorylation phosphoinositide-3 kinase (PI3K) (Murase and McKay, 2006).
Gene_expression (results) of PI3K
15) Confidence 0.17 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.40 Pain Relevance 0.09
Other studies demonstrated that TLR can induce production of reactive oxygen species [29],[30] and PI3K-dependent tumour necrosis factor-?
Gene_expression (production) of PI3K associated with necrosis and cancer
16) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.30 Pain Relevance 0.48

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