INT243845

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
Anatomy Link Frequency
vesicles 1
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 13 99.80 Very High Very High Very High
fluoxetine 15 90.80 High High
monoamine 11 83.24 Quite High
Dopamine 8 74.76 Quite High
sSRI 22 73.28 Quite High
antidepressant 14 71.04 Quite High
depression 6 51.00 Quite High
tricyclic antidepressant 10 42.56 Quite Low
positron emission tomography 17 20.12 Low Low
sNRI 4 14.08 Low Low
Disease Link Frequency Relevance Heat
Agoraphobia 70 94.64 High High
Panic Disorder 151 93.52 High High
Chronic Fatigue Syndrome 40 86.36 High High
Anxiety Disorder 38 61.60 Quite High
Parkinson's Disease 15 61.40 Quite High
Depression 8 60.20 Quite High
Disease Susceptibility 5 54.24 Quite High
Disease 9 39.08 Quite Low
Cognitive Disorder 23 33.72 Quite Low
Phobia 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective and reversible MAO-A inhibitors (RIMAs) exemplified by moclobemide and brofaromine do not require dietary restrictions, have fewer drug interactions than irreversible MAO inhibitors, and are better tolerated.
Localization (tolerated) of MAO
1) Confidence 0.55 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536545 Disease Relevance 0.97 Pain Relevance 0.47
In the brain, while FDOPA is decarboxylated by AADC into 6-[18F]fluorodopamine (FDA), stored in vesicles, and subsequently metabolized by MAO and COMT, FMT is decarboxylated by AADC into FMA which has a low affinity for the vesicular transporter (Endres et al., 1997) and is thereby simply further metabolized by MAO into FPAC and trapped in the tissue.
Localization (metabolized) of MAO in vesicles associated with catechol-o-methyltransferase
2) Confidence 0.34 Published 2007 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2525990 Disease Relevance 0.06 Pain Relevance 0.17
As shown in Table 2[18], there were ten candidate genes including COMT, corticotropin releasing hormone receptor 1 (CRHR1), corticotropin releasing hormone receptor 2 (CRHR2), MAOA, MAOB, NR3C1, POMC, solute carrier family 6 member 4 (SLC6A4), tyrosine hydroxylase (TH), and TPH2 genes.
Localization (releasing) of MAOA associated with catechol-o-methyltransferase
3) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.49 Pain Relevance 0.13
Like tryptamine itself (31,61), tryptamine derivatives including DMT, bufotenine and 5-MeO-DMT are excreted primarily via oxidative deamination and a predominant role for MAO-A is certain in this metabolic pathway (62–66).
Localization (excreted) of MAO
4) Confidence 0.18 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0

General Comments

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