INT243846

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.66
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDC) small molecule metabolic process (DDC) lyase activity (DDC)
cellular nitrogen compound metabolic process (DDC) cellular amino acid metabolic process (DDC) cytoplasm (DDC)
Anatomy Link Frequency
spinal cord 1
neurons 1
vesicles 1
neutrophils 1
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 206 100.00 Very High Very High Very High
Catechol-O-methyltransferase 4 99.82 Very High Very High Very High
Dopamine 141 98.76 Very High Very High Very High
Spinal cord 88 97.68 Very High Very High Very High
alcohol 2 94.96 High High
Nicotine 2 94.24 High High
cocaine 3 93.12 High High
noradrenaline 4 91.76 High High
Dorsal horn 10 88.64 High High
opioid receptor 42 80.64 Quite High
Disease Link Frequency Relevance Heat
Pain 13 78.40 Quite High
Stress 7 78.04 Quite High
Infection 19 68.48 Quite High
Sepsis 47 67.04 Quite High
Adult Respiratory Distress Syndrome 1 62.24 Quite High
Acute Renal Failure 1 60.56 Quite High
Parkinson's Disease 87 59.96 Quite High
INFLAMMATION 12 54.88 Quite High
Neuroblastoma 1 50.84 Quite High
Cognitive Disorder 1 32.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the brain, while FDOPA is decarboxylated by AADC into 6-[18F]fluorodopamine (FDA), stored in vesicles, and subsequently metabolized by MAO and COMT, FMT is decarboxylated by AADC into FMA which has a low affinity for the vesicular transporter (Endres et al., 1997) and is thereby simply further metabolized by MAO into FPAC and trapped in the tissue.
Localization (decarboxylated) of AADC in vesicles associated with catechol-o-methyltransferase
1) Confidence 0.63 Published 2007 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2525990 Disease Relevance 0.06 Pain Relevance 0.17
As we also demonstrate the presence of monoenzymatic AADC neurons in the NHP spinal cord and because DA could be synthesized by non-dopaminergic neurons [78], [79], we speculate that part of the spinally released L-DOPA may be locally converted into dopamine.
Localization (released) of L-DOPA in spinal cord associated with dopamine and spinal cord
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.37
This was confirmed by the fluorescent double labeling against TH and AADC showing that AADC-positive neurons were not colocalized with TH-positive neurons within the A11 group (Fig. 7F–K).
Neg (not) Localization (colocalized) of AADC-positive in neurons
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.22
Human neutrophils were shown to be able to release morphine into the media after exposure to precursors including L-tyrosine, L-DOPA, tetrahydropapaveroline (THP) and reticuline.
Localization (release) of L-DOPA in neutrophils associated with morphine
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.60 Pain Relevance 1.22

General Comments

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